Deep learning in ophthalmology: the technical and clinical considerations

DSW Ting, L Peng, AV Varadarajan, PA Keane… - Progress in retinal and …, 2019 - Elsevier
The advent of computer graphic processing units, improvement in mathematical models and
availability of big data has allowed artificial intelligence (AI) using machine learning (ML) …

Multimodal brain and retinal imaging of dopaminergic degeneration in Parkinson disease

JY Lee, A Martin-Bastida, A Murueta-Goyena… - Nature Reviews …, 2022 - nature.com
Parkinson disease (PD) is a progressive disorder characterized by dopaminergic
neurodegeneration in the brain. The development of parkinsonism is preceded by a long …

Optical coherence tomography and glaucoma

A Geevarghese, G Wollstein, H Ishikawa… - Annual review of …, 2021 - annualreviews.org
Early detection and monitoring are critical to the diagnosis and management of glaucoma, a
progressive optic neuropathy that causes irreversible blindness. Optical coherence …

[HTML][HTML] Adaptive optics imaging of the human retina

SA Burns, AE Elsner, KA Sapoznik, RL Warner… - Progress in retinal and …, 2019 - Elsevier
Adaptive Optics (AO) retinal imaging has provided revolutionary tools to scientists and
clinicians for studying retinal structure and function in the living eye. From animal models to …

Visible-light optical coherence tomography: a review

X Shu, L Beckmann, HF Zhang - Journal of biomedical optics, 2017 - spiedigitallibrary.org
Visible-light optical coherence tomography (vis-OCT) is an emerging imaging modality,
providing new capabilities in both anatomical and functional imaging of biological tissue. It …

[HTML][HTML] Endpoints for clinical trials in ophthalmology

L Schmetterer, H Scholl, G Garhöfer… - Progress in Retinal and …, 2023 - Elsevier
With the identification of novel targets, the number of interventional clinical trials in
ophthalmology has increased. Visual acuity has for a long time been considered the gold …

Review of adaptive optics OCT (AO-OCT): principles and applications for retinal imaging

M Pircher, RJ Zawadzki - Biomedical optics express, 2017 - opg.optica.org
In vivo imaging of the human retina with a resolution that allows visualization of cellular
structures has proven to be essential to broaden our knowledge about the physiology of this …

Twenty-five years of clinical applications using adaptive optics ophthalmoscopy

JIW Morgan, TYP Chui, K Grieve - Biomedical optics express, 2022 - opg.optica.org
Twenty-five years ago, adaptive optics (AO) was combined with fundus photography,
thereby initiating a new era in the field of ophthalmic imaging. Since that time, clinical …

Adaptive optics: principles and applications in ophthalmology

E Akyol, AM Hagag, S Sivaprasad, AJ Lotery - Eye, 2021 - nature.com
This is a comprehensive review of the principles and applications of adaptive optics (AO) in
ophthalmology. It has been combined with flood illumination ophthalmoscopy, scanning …

Discovery and clinical translation of novel glaucoma biomarkers

G Beykin, AM Norcia, VJ Srinivasan, A Dubra… - Progress in Retinal and …, 2021 - Elsevier
Glaucoma and other optic neuropathies are characterized by progressive dysfunction and
loss of retinal ganglion cells and their axons. Given the high prevalence of glaucoma-related …