Signaling pathways and targeted therapy for myocardial infarction
Q Zhang, L Wang, S Wang, H Cheng, L Xu… - Signal transduction and …, 2022 - nature.com
Although the treatment of myocardial infarction (MI) has improved considerably, it is still a
worldwide disease with high morbidity and high mortality. Whilst there is still a long way to …
worldwide disease with high morbidity and high mortality. Whilst there is still a long way to …
[HTML][HTML] Molecular machinery and interplay of apoptosis and autophagy in coronary heart disease
Y Dong, H Chen, J Gao, Y Liu, J Li, J Wang - Journal of molecular and …, 2019 - Elsevier
Coronary heart disease (CHD) is a common heart disease and the leading cause of
cardiovascular death. Apoptosis and autophagy are two forms of programmed cell deaths …
cardiovascular death. Apoptosis and autophagy are two forms of programmed cell deaths …
New insights into the role of mTOR signaling in the cardiovascular system
The mTOR (mechanistic target of rapamycin) is a master regulator of several crucial cellular
processes, including protein synthesis, cellular growth, proliferation, autophagy, lysosomal …
processes, including protein synthesis, cellular growth, proliferation, autophagy, lysosomal …
[HTML][HTML] Long noncoding RNA p21 enhances autophagy to alleviate endothelial progenitor cells damage and promote endothelial repair in hypertension through …
C Li, L Lin, L Zhang, R Xu, X Chen, J Ji, Y Li - Pharmacological Research, 2021 - Elsevier
Vascular damage of hypertension has been the focus of hypertension treatment, and
endothelial progenitor cells (EPCs) play an important role in the repair of vascular …
endothelial progenitor cells (EPCs) play an important role in the repair of vascular …
A review of the molecular mechanisms underlying the development and progression of cardiac remodeling
Pathological molecular mechanisms involved in myocardial remodeling contribute to alter
the existing structure of the heart, leading to cardiac dysfunction. Among the complex …
the existing structure of the heart, leading to cardiac dysfunction. Among the complex …
Effect of rapamycin on aging and age-related diseases—past and future
In 2009, rapamycin was reported to increase the lifespan of mice when implemented later in
life. This observation resulted in a sea-change in how researchers viewed aging. This was …
life. This observation resulted in a sea-change in how researchers viewed aging. This was …
Rapamycin regulates the balance between cardiomyocyte apoptosis and autophagy in chronic heart failure by inhibiting mTOR signaling
G Gao, W Chen, M Yan, J Liu… - International …, 2020 - spandidos-publications.com
The progressive loss of cardiomyocytes caused by cell death leads to cardiac dysfunction
and heart failure (HF). Rapamycin has been shown to be cardioprotective in pressure …
and heart failure (HF). Rapamycin has been shown to be cardioprotective in pressure …
Cardiomyocyte death: mechanisms and translational implications
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide.
Although treatments have improved, development of novel therapies for patients with CVD …
Although treatments have improved, development of novel therapies for patients with CVD …
An overview of the molecular mechanisms associated with myocardial ischemic injury: state of the art and translational perspectives
Cardiovascular disease is the leading cause of death in western countries. Among
cardiovascular diseases, myocardial infarction represents a life-threatening condition …
cardiovascular diseases, myocardial infarction represents a life-threatening condition …
Mammalian target of rapamycin signaling in cardiac physiology and disease
S Sciarretta, M Volpe, J Sadoshima - Circulation research, 2014 - Am Heart Assoc
The protein kinase mammalian or mechanistic target of rapamycin (mTOR) is an atypical
serine/threonine kinase that exerts its main cellular functions by interacting with specific …
serine/threonine kinase that exerts its main cellular functions by interacting with specific …