Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy
RGG Russell, NB Watts, FH Ebetino… - Osteoporosis …, 2008 - Springer
Bisphosphonates (BPs) are well established as the leading drugs for the treatment of
osteoporosis. There is new knowledge about how they work. The differences that exist …
osteoporosis. There is new knowledge about how they work. The differences that exist …
Pharmacological actions of statins: a critical appraisal in the management of cancer
P Gazzerro, MC Proto, G Gangemi, AM Malfitano… - Pharmacological …, 2012 - Elsevier
Statins, among the most commonly prescribed drugs worldwide, are cholesterol-lowering
agents used to manage and prevent cardiovascular and coronary heart diseases. Recently …
agents used to manage and prevent cardiovascular and coronary heart diseases. Recently …
Biochemical and molecular mechanisms of action of bisphosphonates
MJ Rogers, JC Crockett, FP Coxon, J Mönkkönen - Bone, 2011 - Elsevier
This review describes the key discoveries over the last 15 years that have led to a clearer
understanding of the molecular mechanisms by which bisphosphonate drugs inhibit bone …
understanding of the molecular mechanisms by which bisphosphonate drugs inhibit bone …
Molecular mechanisms of action of bisphosphonates and new insights into their effects outside the skeleton
MJ Rogers, J Mönkkönen, MA Munoz - Bone, 2020 - Elsevier
Bisphosphonates (BP) are a class of calcium-binding drug used to prevent bone resorption
in skeletal disorders such as osteoporosis and metastatic bone disease. They act by …
in skeletal disorders such as osteoporosis and metastatic bone disease. They act by …
Cholesterol and beyond-The role of the mevalonate pathway in cancer biology
A Göbel, M Rauner, LC Hofbauer… - Biochimica et Biophysica …, 2020 - Elsevier
Cancer is a multifaceted global disease. Transformation of a normal to a malignant cell takes
several steps, including somatic mutations, epigenetic alterations, metabolic reprogramming …
several steps, including somatic mutations, epigenetic alterations, metabolic reprogramming …
Molecular mechanisms of action of bisphosphonates: current status
Purpose: Bisphosphonates are currently the most important class of antiresorptive agents
used in the treatment of metabolic bone diseases, including tumor-associated osteolysis and …
used in the treatment of metabolic bone diseases, including tumor-associated osteolysis and …
Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy
The bisphosphonates (BPs) are well established as the treatments of choice for disorders of
excessive bone resorption, including Paget's disease of bone, myeloma and bone …
excessive bone resorption, including Paget's disease of bone, myeloma and bone …
Biomedical applications of bisphosphonates
EV Giger, B Castagner, JC Leroux - Journal of Controlled Release, 2013 - Elsevier
Since their discovery over 100years ago, bisphosphonates have been used industrially as
corrosion inhibitors and complexing agents. With the discovery of their pharmacological …
corrosion inhibitors and complexing agents. With the discovery of their pharmacological …
Recent advances in understanding the mechanism of action of bisphosphonates
FP Coxon, K Thompson, MJ Rogers - Current opinion in pharmacology, 2006 - Elsevier
Bisphosphonates (BPs) are widely used in the treatment of diseases associated with
excessive osteoclast-mediated bone resorption, such as osteoporosis. Although several …
excessive osteoclast-mediated bone resorption, such as osteoporosis. Although several …
Bisphosphonates: molecular mechanisms of action and effects on bone cells, monocytes and macrophages
AJ Roelofs, K Thompson, FH Ebetino… - Current …, 2010 - ingentaconnect.com
Bisphosphonates are widely used in the treatment of diseases involving excessive bone
resorption, such as osteoporosis, cancer-associated bone disease, and Paget's disease of …
resorption, such as osteoporosis, cancer-associated bone disease, and Paget's disease of …