Motivation: Comprehensive analysis of genome-wide molecular data challenges
bioinformatics methodology in terms of intuitive visualization with single-sample resolution …

Simple Summary Data from multiple omics domains were increasingly generated in large-
scale tumour studies to enhance our understanding of molecular mechanisms of cancer. We …

Wood-decay fungi contain the cellular mechanisms to decompose such plant cell wall
components as cellulose, hemicellulose, and lignin. A multi-omics approach to the …

Mutually linked expression and methylation dynamics in the brain govern genome
regulation over the whole lifetime with an impact on cognition, psychological disorders, and …

Aim: We present here a novel method that enables unraveling the interplay between gene
expression and DNA methylation in complex diseases such as cancer. Materials & methods …

DNA methylation patterns have been shown to change throughout the normal aging
process. Several studies have found epigenetic aging markers using age predictors, but …

The endless enhancement and decreasing charges of a complete human genome have
given rise to fast acceptance of genetic and genomic information at both research institutions …

The development and decaying costs for highthroughput bio-molecular analytics give rise to
huge and still increasing amounts of data collected in the context of modern 'omics' realms …

Application of new high-throughput technologies in molecular medicine collects massive
data for hundreds to thousands of persons in large cohort studies by characterizing the …

It is generally accepted that epigenetic modifications, such as DNA and histone
methylations, affect transcription and that a gene's transcription feeds back on its epigenetic …