Mitochondrial permeability transition (mPT) is a phenomenon that abruptly causes the flux of
low molecular weight solutes (molecular weight up to 1,500) across the generally …

Mitochondria are bioenergetic, biosynthetic, and signaling organelles that are integral in
stress sensing to allow for cellular adaptation to the environment. Therefore, it is not …

Glycolysis has long been considered as the major metabolic process for energy production
and anabolic growth in cancer cells. Although such a view has been instrumental for the …

Given that the PI3K/AKT pathway has manifested its compelling influence on multiple
cellular process, we further review the roles of hyperactivation of PI3K/AKT pathway in …

The emergence of drug resistance is a major challenge for oncologists. Resistance can be
categorized as acquired or intrinsic; the alteration of several biological mechanisms …

Drug resistance represents a major obstacle in cancer management, and the mechanisms
underlying stress adaptation of cancer cells in response to therapy-induced hostile …

The horizontal transfer of mtDNA and its role in mediating resistance to therapy and an exit
from dormancy have never been investigated. Here we identified the full mitochondrial …

Major progress has been made in defining the basis of the mitochondrial permeability
transition, a Ca2+‐dependent permeability increase of the inner membrane that has puzzled …

Mitochondrial permeability transition pore (mPTP)-dependent cell death is a form of necrotic
cell death that is driven by mitochondrial dysfunction by the opening of the mPTP and is …

Ca 2+ ions are key second messengers in both excitable and non-excitable cells. Owing to
the rather pleiotropic nature of Ca 2+ transporters and other Ca 2+-binding proteins …