Genetic engineering has provided humans the ability to transform organisms by direct
manipulation of genomes within a broad range of applications including agriculture (eg, GM …

The CRISPR-Cas system is a powerful tool for in vivo editing the genome of most organisms,
including man. During the years this technique has been applied in several fields, such as …

Background This article explores the reasons in favour of revising and extending the current
14-day statutory limit to maintaining human embryos in culture. This limit is enshrined in law …

Background Our human societies and certainly also (bio) medicine are more and more
permeated with technology. There seems to be an increasing awareness among bioethicists …

Despite the advent of CRISPR, safe and effective gene editing for human enhancement
remains well beyond our current technological capabilities. For the discussion about …

With the advent of efficient, easy-to-use genome editing by CRISPR–Cas9, editing human
embryos is now possible, providing tremendous opportunities to study gene function and …

In the past decade, scientific developments in human germline genome editing (GGE) have
reinvigorated questions about research ethics, responsible innovation, and what it means to …

STUDY QUESTION What are the reasons for or against the future clinical application of
germline genome modification (GGM)? SUMMARY ANSWER A total of 169 reasons were …

Abstract Background Clustered Regularly Interspaced Short Palindromic Repeats-
associated (CRISPR-Cas) technology may allow for efficient and highly targeted gene …

Technological developments in gene editing raise high expectations for clinical applications,
including editing of the germline. The European Society of Human Reproduction and …