[HTML][HTML] Dopamine transporter membrane mobility is bidirectionally regulated by phosphorylation and palmitoylation

M Shetty, DE Bolland, J Morrell, BD Grove… - Current Research in …, 2023 - Elsevier
The primary regulator of dopamine availability in the brain is the dopamine transporter
(DAT), a plasma membrane protein that drives reuptake of released dopamine from the …

Leaky lessons learned: Efflux prone dopamine transporter variant reveals sex and circuit specific contributions of D2 receptor signalling to neuropsychiatric disease

FP Mayer, A Stewart, RD Blakely - Basic & Clinical …, 2024 - Wiley Online Library
Aberrant dopamine (DA) signalling has been implicated in various neuropsychiatric
disorders, including attention‐deficit/hyperactivity disorder (ADHD), autism spectrum …

Nanoscopic dopamine transporter distribution and conformation are inversely regulated by excitatory drive and D2 autoreceptor activity

MD Lycas, AL Ejdrup, AT Sørensen, NO Haahr… - Cell reports, 2022 - cell.com
The nanoscopic organization and regulation of individual molecular components in
presynaptic varicosities of neurons releasing modulatory volume neurotransmitters like …

Dopamine transporter trafficking and Rit2 GTPase: Mechanism of action and in vivo impact

RR Fagan, PJ Kearney, CG Sweeney, D Luethi… - Journal of Biological …, 2020 - ASBMB
Following its evoked release, dopamine (DA) signaling is rapidly terminated by presynaptic
reuptake, mediated by the cocaine-sensitive DA transporter (DAT). DAT surface availability …

[HTML][HTML] Kappa opioid receptor antagonism rescues genetic perturbation of dopamine homeostasis: Molecular, physiological and behavioral consequences

FP Mayer, A Stewart, DR Varman, AE Moritz, JD Foster… - BioRxiv, 2023 - ncbi.nlm.nih.gov
Aberrant dopamine (DA) signaling is implicated in schizophrenia, bipolar disorder (BPD),
autism spectrum disorder (ASD), substance use disorder, and attention-deficit/hyperactivity …

Novel fluorescent ligands enable single-molecule localization microscopy of the dopamine transporter

DA Guthrie, C Klein Herenbrink, MD Lycas… - ACS chemical …, 2020 - ACS Publications
The dopamine transporter (DAT) is critical for spatiotemporal control of dopaminergic
neurotransmission and is the target for therapeutic agents, including ADHD medications …

The story of the dopamine transporter PET tracer LBT-999: from conception to clinical use

S Chalon, J Vercouillie, P Payoux, JB Deloye… - Frontiers in …, 2019 - frontiersin.org
The membrane dopamine transporter (DAT) is involved in a number of brain disorders and
its exploration by positron emission tomography (PET) imaging is highly relevant for the …

Motor transitions' peculiarity of heterozygous DAT rats when offspring of an unconventional KOxWT mating

C Carbone, A Brancato, A Adinolfi, SLML Russo… - Neuroscience, 2020 - Elsevier
Causal factors of psychiatric diseases are unclear, due to gene× environment interactions.
Evaluation of consequences, after a dopamine-transporter (DAT) gene knock-out (DAT-KO) …

Ligand-conjugated quantum dots for fast sub-diffraction protein tracking in acute brain slices

LB Thal, VR Mann, D Sprinzen, JR McBride… - Biomaterials …, 2020 - pubs.rsc.org
Semiconductor quantum dots (QDs) have demonstrated utility in long-term single particle
tracking of membrane proteins in live cells in culture. To extend the superior optical …

Genetic and epigenetic signatures associated with plasma oxytocin levels in children and adolescents with autism spectrum disorder

SK Siecinski, SN Giamberardino, M Spanos… - Autism …, 2023 - Wiley Online Library
Abstract Oxytocin (OT), the brain's most abundant neuropeptide, plays an important role in
social salience and motivation. Clinical trials of the efficacy of OT in autism spectrum …