[HTML][HTML] The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth
Cancers represent complex ecosystems comprising tumor cells and a multitude of non-
cancerous cells, embedded in an altered extracellular matrix. The tumor microenvironment …
cancerous cells, embedded in an altered extracellular matrix. The tumor microenvironment …
Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives
X Mao, J Xu, W Wang, C Liang, J Hua, J Liu, B Zhang… - Molecular cancer, 2021 - Springer
Abstract Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin,
phenotypic and functional heterogeneity, are the most essential components of the tumor …
phenotypic and functional heterogeneity, are the most essential components of the tumor …
Hallmarks of response, resistance, and toxicity to immune checkpoint blockade
G Morad, BA Helmink, P Sharma, JA Wargo - Cell, 2021 - cell.com
Unprecedented advances have been made in cancer treatment with the use of immune
checkpoint blockade (ICB). However, responses are limited to a subset of patients, and …
checkpoint blockade (ICB). However, responses are limited to a subset of patients, and …
Pancreatic cancer: Advances and challenges
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers. Significant
efforts have largely defined major genetic factors driving PDAC pathogenesis and …
efforts have largely defined major genetic factors driving PDAC pathogenesis and …
Clinical and therapeutic relevance of cancer-associated fibroblasts
Cancer-associated fibroblasts (CAFs) found in primary and metastatic tumours are highly
versatile, plastic and resilient cells that are actively involved in cancer progression through …
versatile, plastic and resilient cells that are actively involved in cancer progression through …
Liver tumour immune microenvironment subtypes and neutrophil heterogeneity
The heterogeneity of the tumour immune microenvironment (TIME), organized by various
immune and stromal cells, is a major contributing factor of tumour metastasis, relapse and …
immune and stromal cells, is a major contributing factor of tumour metastasis, relapse and …
Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancer
J Qi, H Sun, Y Zhang, Z Wang, Z Xun, Z Li… - Nature …, 2022 - nature.com
Colorectal cancer (CRC) is among the most common malignancies with limited treatments
other than surgery. The tumor microenvironment (TME) profiling enables the discovery of …
other than surgery. The tumor microenvironment (TME) profiling enables the discovery of …
A framework for advancing our understanding of cancer-associated fibroblasts
Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment
with diverse functions, including matrix deposition and remodelling, extensive reciprocal …
with diverse functions, including matrix deposition and remodelling, extensive reciprocal …
Tumor microenvironment as a therapeutic target in cancer
Y **ao, D Yu - Pharmacology & therapeutics, 2021 - Elsevier
Tumor microenvironment denotes the non-cancerous cells and components presented in
the tumor, including molecules produced and released by them. The constant interactions …
the tumor, including molecules produced and released by them. The constant interactions …
The cancer-immunity cycle: Indication, genotype, and immunotype
The cancer-immunity cycle provides a framework to understand the series of events that
generate anti-cancer immune responses. It emphasizes the iterative nature of the response …
generate anti-cancer immune responses. It emphasizes the iterative nature of the response …