[HTML][HTML] The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth

KE De Visser, JA Joyce - Cancer cell, 2023 - cell.com
Cancers represent complex ecosystems comprising tumor cells and a multitude of non-
cancerous cells, embedded in an altered extracellular matrix. The tumor microenvironment …

Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives

X Mao, J Xu, W Wang, C Liang, J Hua, J Liu, B Zhang… - Molecular cancer, 2021 - Springer
Abstract Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin,
phenotypic and functional heterogeneity, are the most essential components of the tumor …

Hallmarks of response, resistance, and toxicity to immune checkpoint blockade

G Morad, BA Helmink, P Sharma, JA Wargo - Cell, 2021 - cell.com
Unprecedented advances have been made in cancer treatment with the use of immune
checkpoint blockade (ICB). However, responses are limited to a subset of patients, and …

Pancreatic cancer: Advances and challenges

CJ Halbrook, CA Lyssiotis, MP di Magliano, A Maitra - Cell, 2023 - cell.com
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers. Significant
efforts have largely defined major genetic factors driving PDAC pathogenesis and …

Clinical and therapeutic relevance of cancer-associated fibroblasts

Y Chen, KM McAndrews, R Kalluri - Nature reviews Clinical oncology, 2021 - nature.com
Cancer-associated fibroblasts (CAFs) found in primary and metastatic tumours are highly
versatile, plastic and resilient cells that are actively involved in cancer progression through …

Liver tumour immune microenvironment subtypes and neutrophil heterogeneity

R Xue, Q Zhang, Q Cao, R Kong, X **ang, H Liu… - Nature, 2022 - nature.com
The heterogeneity of the tumour immune microenvironment (TIME), organized by various
immune and stromal cells, is a major contributing factor of tumour metastasis, relapse and …

Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancer

J Qi, H Sun, Y Zhang, Z Wang, Z Xun, Z Li… - Nature …, 2022 - nature.com
Colorectal cancer (CRC) is among the most common malignancies with limited treatments
other than surgery. The tumor microenvironment (TME) profiling enables the discovery of …

A framework for advancing our understanding of cancer-associated fibroblasts

E Sahai, I Astsaturov, E Cukierman… - Nature Reviews …, 2020 - nature.com
Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment
with diverse functions, including matrix deposition and remodelling, extensive reciprocal …

Tumor microenvironment as a therapeutic target in cancer

Y **ao, D Yu - Pharmacology & therapeutics, 2021 - Elsevier
Tumor microenvironment denotes the non-cancerous cells and components presented in
the tumor, including molecules produced and released by them. The constant interactions …

The cancer-immunity cycle: Indication, genotype, and immunotype

I Mellman, DS Chen, T Powles, SJ Turley - Immunity, 2023 - cell.com
The cancer-immunity cycle provides a framework to understand the series of events that
generate anti-cancer immune responses. It emphasizes the iterative nature of the response …