Numerous natural products originated from Chinese herbal medicine exhibit anti-cancer
activities, including anti-proliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects …

Shikonin and its derivatives, isolated from traditional medicinal plant species of the genus
Lithospermum, Alkanna, Arnebia, Anchusa, Onosma, and Echium belonging to the …

Phytochemicals gained considerable interest during the past years as source to develop
new treatment options for chemoprevention and cancer therapy. Motivated by the fact that a …

Background Growth differentiation factor 15 (GDF15) is a member of the TGF-β superfamily,
and evidence suggests that a substantial amount of GDF15 is secreted in various human …

Despite massive investments in drug research and development, the significant decline in
the number of new drugs approved or translated to clinical use raises the question, whether …

Abstract The 1, 4-naphthoquinones (1, 4-NQs) are a diverse group of natural products found
in every kingdom of life. Plants, including many horticultural species, collectively synthesize …

Purpose: Osteosarcoma is the most common primary bone cancer and is notorious for
pulmonary metastasis, representing a major threat to pediatric patients. An effective drug …

Shikonin is a natural compound isolated from herbs and traditional medicines that have
been used in a number of countries to treat various illnesses including inflammation, virus …

The complex interaction between tumor-associated macrophages (TAMs) and tumor cells
through several soluble factors and signaling is essential for colorectal cancer (CRC) …

Simple Summary Prostate carcinoma (PCa) is the most common tumor in men with an
increasing age-associated risk. Several therapy strategies, one of which is docetaxel (DX) …