Polyamine Metabolism in Leishmania Parasites: A Promising Therapeutic Target
Parasites of the genus Leishmania cause a variety of devastating and often fatal diseases in
humans and domestic animals worldwide. The need for new therapeutic strategies is urgent …
humans and domestic animals worldwide. The need for new therapeutic strategies is urgent …
An overview of leishmanization experience: A successful control measure and a tool to evaluate candidate vaccines
Leishmanization (LZ) is an intradermal inoculation of live Leishmania to induce an artificial
cutaneous leishmaniasis (CL) lesion in a covered part of the body to protect against further …
cutaneous leishmaniasis (CL) lesion in a covered part of the body to protect against further …
Impact of Genetic Diversity and Genome Plasticity of Leishmania spp. in Treatment and the Search for Novel Chemotherapeutic Targets
AMM Santi, SMF Murta - Frontiers in Cellular and Infection …, 2022 - frontiersin.org
Leishmaniasis is one of the major public health concerns in Latin America, Africa, Asia, and
Europe. The absence of vaccines for human use and the lack of effective vector control …
Europe. The absence of vaccines for human use and the lack of effective vector control …
Mutations in an Aquaglyceroporin as a Proven Marker of Antimony Clinical Resistance in the Parasite Leishmania donovani
JE Potvin, P Leprohon, M Queffeulou… - Clinical Infectious …, 2021 - academic.oup.com
Background Antimonial drugs have long been the mainstay to treat visceral leishmaniasis.
Their use has been discontinued in the Indian subcontinent because of drug resistance, but …
Their use has been discontinued in the Indian subcontinent because of drug resistance, but …
Translational reprogramming as a driver of antimony-drug resistance in Leishmania
Leishmania is a unicellular protozoan that has a limited transcriptional control and mostly
uses post-transcriptional regulation of gene expression, although the molecular …
uses post-transcriptional regulation of gene expression, although the molecular …
[HTML][HTML] Leishmania spp. genetic factors associated with cutaneous leishmaniasis antimony pentavalent drug resistance: a systematic review
BACKGROUND Leishmaniasis is a neglected zoonosis caused by parasites of Leishmania
spp. The main drug used to treat cutaneous leishmaniasis (CL) is the antimoniate of …
spp. The main drug used to treat cutaneous leishmaniasis (CL) is the antimoniate of …
HAS 1: A natural product from soil-isolated Streptomyces species with potent activity against cutaneous leishmaniasis caused by Leishmania tropica
Cutaneous Leishmaniasis (CL) is a neglected tropical disease, classified by the World
Health Organization (WHO) as one of the most unrestrained diseases. The Syrian war and …
Health Organization (WHO) as one of the most unrestrained diseases. The Syrian war and …
[HTML][HTML] MicroRNAs expression induces apoptosis of macrophages in response to leishmania major (MRHO/IR/75/ER): an in-vitro and in-vivo study
Background: We aimed to investigate the effect of miR-15a mimic and inhibitor of miR-155
expression on apoptosis induction in macrophages infected with Iranian strain of …
expression on apoptosis induction in macrophages infected with Iranian strain of …
Next-generation molecular surveillance of TriTryp diseases
Elimination programs targeting TriTryp diseases (Leishmaniasis, Chagas' disease, human
African trypanosomiasis) significantly reduced the number of cases. Continued surveillance …
African trypanosomiasis) significantly reduced the number of cases. Continued surveillance …
Contribution of epidermal growth factor (EGF) in the treatment of cutaneous leishmaniasis caused by Leishmania major in BALB/c mice
Cutaneous leishmaniasis (CL) is a tropical disease that can cause chronic lesions and leave
life-long scars, leading to social stigmatization and psychological disorders. Using growth …
life-long scars, leading to social stigmatization and psychological disorders. Using growth …