Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

H Tian, T Zhang, S Qin, Z Huang, L Zhou, J Shi… - Journal of hematology & …, 2022 - Springer
Poor targeting of therapeutics leading to severe adverse effects on normal tissues is
considered one of the obstacles in cancer therapy. To help overcome this, nanoscale drug …

Nanoparticle surface functionalization: how to improve biocompatibility and cellular internalization

G Sanità, B Carrese, A Lamberti - Frontiers in molecular biosciences, 2020 - frontiersin.org
The use of nanoparticles (NP) in diagnosis and treatment of many human diseases,
including cancer, is of increasing interest. However, cytotoxic effects of NPs on cells and the …

New opportunities and old challenges in the clinical translation of nanotheranostics

PJ Gawne, M Ferreira, M Papaluca, J Grimm… - Nature reviews …, 2023 - nature.com
Nanoparticle-based systems imbued with both diagnostic and therapeutic functions, known
as nanotheranostics, have enabled remarkable progress in guiding focal therapy, inducing …

Fenton-reaction-acceleratable magnetic nanoparticles for ferroptosis therapy of orthotopic brain tumors

Z Shen, T Liu, Y Li, J Lau, Z Yang, W Fan, Z Zhou… - ACS …, 2018 - ACS Publications
Cancer is one of the leading causes of morbidity and mortality in the world, but more cancer
therapies are needed to complement existing regimens due to problems of existing cancer …

Nanomaterial-based blood-brain-barrier (BBB) crossing strategies

J **e, Z Shen, Y Anraku, K Kataoka, X Chen - Biomaterials, 2019 - Elsevier
Increasing attention has been paid to the diseases of central nervous system (CNS). The
penetration efficiency of most CNS drugs into the brain parenchyma is rather limited due to …

Iron Oxide Nanoparticles as T1 Contrast Agents for Magnetic Resonance Imaging: Fundamentals, Challenges, Applications, and Prospectives

M Jeon, MV Halbert, ZR Stephen… - Advanced Materials, 2021 - Wiley Online Library
Gadolinium‐based chelates are a mainstay of contrast agents for magnetic resonance
imaging (MRI) in the clinic. However, their toxicity elicits severe side effects and the Food …

[HTML][HTML] Multifunctional magnetic iron oxide nanoparticles: an advanced platform for cancer theranostics

S Zhao, X Yu, Y Qian, W Chen, J Shen - Theranostics, 2020 - ncbi.nlm.nih.gov
Multifunctional magnetic nanoparticles and derivative nanocomposites have aroused great
concern for multimode imaging and cancer synergistic therapies in recent years. Among the …

Nanogels: Synthesis, properties, and recent biomedical applications

QY Duan, YX Zhu, HR Jia, SH Wang, FG Wu - Progress in Materials …, 2023 - Elsevier
Nanogels, also termed hydrogel nanoparticles, have the properties and functions of both
nanomaterials and hydrogels. Till date, a considerable number of nanogels have been …

Structure–relaxivity relationships of magnetic nanoparticles for magnetic resonance imaging

Z Zhou, L Yang, J Gao, X Chen - Advanced Materials, 2019 - Wiley Online Library
Magnetic nanoparticles (MNPs) have been extensively explored as magnetic resonance
imaging (MRI) contrast agents. With the increasing complexity in the structure of modern …

An AND Logic Gate for Magnetic‐Resonance‐Imaging‐Guided Ferroptosis Therapy of Tumors

Q Fan, W **ong, H Zhou, J Yang, J Feng, Z Li… - Advanced …, 2023 - Wiley Online Library
To improve the magnetic resonance imaging (MRI) efficiency and ferroptosis therapy
efficacy of exceedingly small magnetic iron oxide nanoparticles (IO,< 5 nm) for tumors via …