▪ Abstract Exciting breakthroughs in the last two years have begun to elucidate the structural
basis of cellular immune recognition. Crystal structures have been determined for full-length …

Although efficient at reacting to foreign antigen in the context of MHC, mature T cells do not
normally react to self antigens presented by self MHC. In this review, Harald von Boehmer …

Posttransplantation cyclophosphamide (PTCy) recently has had a marked impact on human
allogeneic hematopoietic cell transplantation (HCT). Yet our understanding of how PTCy …

Despite lack of tumor control in many models, spontaneous T cell priming occurs frequently
in response to a growing tumor. However, the innate immune mechanisms that promote …

Abstract PD-1, a 55 kDa transmembrane protein containing an immunoreceptor tyrosine-
based inhibitory motif, is induced in lymphocytes and monocytic cells following activation …

Comparative genomic hybridization produces a map of DNA sequence copy number as a
function of chromosomal location throughout the entire genome. Differentially labeled test …

Abstract Antigen-specific CD8+ T-cell tolerance, induced by myeloid-derived suppressor
cells (MDSCs), is one of the main mechanisms of tumor escape. Using in vivo models, we …

Elimination of CD25+ T cells, which constitute 5-10% of peripheral CD4+ T cells in normal
naive mice, leads to spontaneous development of various autoimmune diseases. These …

Although increased circulating tumor antigen-specific CD8+ T cells can be achieved by
vaccination or adoptive transfer, tumor progression nonetheless often occurs through …

During activation, T cells express receptors for receiving positive and negative costimulatory
signals. Here we identify the B and T lymphocyte attenuator (BTLA), an immunoglobulin …