Covering: 2000 up to 2018 The cytochromes P450 (P450s) are a superfamily of heme-
containing monooxygenases that perform diverse catalytic roles in many species, including …

Cyclodipeptides (CDP) represent a diverse family of small, highly stable, cyclic peptides that
are produced as secondary functional metabolites or side products of protein metabolism by …

Microorganisms are remarkable chemists, with enzymes as their tools for executing multi-
step syntheses to yield myriad natural products. Microbial synthetic aptitudes are illustrated …

We report our investigation of the utility of peptide crosslinking cytochrome P450 enzymes
from biarylitide biosynthesis to generate a range of cyclic tripeptides from simple synthons …

Metschnikowia pulcherrima synthesises the pigment pulcherrimin, from cyclodileucine (cyclo
(Leu‐Leu)) as a precursor, and exhibits strong antifungal activity against notorious plant …

Covering: up to 2012 We review here work on the biosynthesis of diketopiperazines (DKPs),
a large class of natural products with noteworthy biological activities, focusing on the …

The dimeric diketopiperazine (DKPs) alkaloids are a diverse family of natural products (NPs)
whose unique structural architectures and biological activities have inspired the …

Aminoacyl-tRNAs were long thought to be involved solely in ribosome-dependent protein
synthesis and essential primary metabolism processes, such as targeted protein …

Secondary metabolites are key in how organisms from all domains of life interact with their
environment and each other. The iron-binding molecule pulcherrimin was described a …

Peptide side chain cross-linking is an important feature of many natural products, with an
increasing number of examples catalyzed by cytochrome P450s being reported from …