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The emergence of adaptive laboratory evolution as an efficient tool for biological discovery and industrial biotechnology
Harnessing the process of natural selection to obtain and understand new microbial
phenotypes has become increasingly possible due to advances in culturing techniques …
phenotypes has become increasingly possible due to advances in culturing techniques …
Mechanisms and concepts in RNA virus population dynamics and evolution
RNA viruses are unique in their evolutionary capacity, exhibiting high mutation rates and
frequent recombination. They rapidly adapt to environmental changes, such as shifts in …
frequent recombination. They rapidly adapt to environmental changes, such as shifts in …
[HTML][HTML] Population immunity predicts evolutionary trajectories of SARS-CoV-2
The large-scale evolution of the SARS-CoV-2 virus has been marked by rapid turnover of
genetic clades. New variants show intrinsic changes, notably increased transmissibility, and …
genetic clades. New variants show intrinsic changes, notably increased transmissibility, and …
The landscape of antibody binding affinity in SARS-CoV-2 Omicron BA. 1 evolution
The Omicron BA. 1 variant of SARS-CoV-2 escapes convalescent sera and monoclonal
antibodies that are effective against earlier strains of the virus. This immune evasion is …
antibodies that are effective against earlier strains of the virus. This immune evasion is …
Steering and controlling evolution—from bioengineering to fighting pathogens
Control interventions steer the evolution of molecules, viruses, microorganisms or other cells
towards a desired outcome. Applications range from engineering biomolecules and …
towards a desired outcome. Applications range from engineering biomolecules and …
Binding affinity landscapes constrain the evolution of broadly neutralizing anti-influenza antibodies
Over the past two decades, several broadly neutralizing antibodies (bnAbs) that confer
protection against diverse influenza strains have been isolated. Structural and biochemical …
protection against diverse influenza strains have been isolated. Structural and biochemical …
Protein ensembles link genotype to phenotype
Classically, phenotype is what is observed, and genotype is the genetic makeup. Statistical
studies aim to project phenotypic likelihoods of genotypic patterns. The traditional genotype …
studies aim to project phenotypic likelihoods of genotypic patterns. The traditional genotype …
Mutational biases favor complexity increases in protein interaction networks after gene duplication
Biological systems can gain complexity over time. While some of these transitions are likely
driven by natural selection, the extent to which they occur without providing an adaptive …
driven by natural selection, the extent to which they occur without providing an adaptive …
[HTML][HTML] From genotypes to organisms: State-of-the-art and perspectives of a cornerstone in evolutionary dynamics
Understanding how genotypes map onto phenotypes, fitness, and eventually organisms is
arguably the next major missing piece in a fully predictive theory of evolution. We refer to this …
arguably the next major missing piece in a fully predictive theory of evolution. We refer to this …
Viral evolution shaped by host proteostasis networks
Understanding the factors that shape viral evolution is critical for develo** effective
antiviral strategies, accurately predicting viral evolution, and preventing pandemics. One …
antiviral strategies, accurately predicting viral evolution, and preventing pandemics. One …