A joint NCBI and EMBL-EBI transcript set for clinical genomics and research
Comprehensive genome annotation is essential to understand the impact of clinically
relevant variants. However, the absence of a standard for clinical reporting and browser …
relevant variants. However, the absence of a standard for clinical reporting and browser …
Applications of deep learning in understanding gene regulation
Gene regulation is a central topic in cell biology. Advances in omics technologies and the
accumulation of omics data have provided better opportunities for gene regulation studies …
accumulation of omics data have provided better opportunities for gene regulation studies …
PanglaoDB: a web server for exploration of mouse and human single-cell RNA sequencing data
Single-cell RNA sequencing is an increasingly used method to measure gene expression at
the single cell level and build cell-type atlases of tissues. Hundreds of single-cell …
the single cell level and build cell-type atlases of tissues. Hundreds of single-cell …
An atlas of the protein-coding genes in the human, pig, and mouse brain
INTRODUCTION The brain is the most complex organ of the mammalian body, boasting a
diverse physiology combined with intricate cellular organization. In an effort to expand our …
diverse physiology combined with intricate cellular organization. In an effort to expand our …
RNA polymerase II dynamics shape enhancer–promoter interactions
How enhancers control target gene expression over long genomic distances remains an
important unsolved problem. Here we investigated enhancer–promoter communication by …
important unsolved problem. Here we investigated enhancer–promoter communication by …
Unlocking the non-IgE-mediated pseudo-allergic reaction puzzle with mas-related G-protein coupled receptor member X2 (MRGPRX2)
Mas-related G-protein coupled receptor member X2 (MRGPRX2) is a class A GPCR
expressed on mast cells. Mast cells are granulated tissue-resident cells known for host cell …
expressed on mast cells. Mast cells are granulated tissue-resident cells known for host cell …
Predicting RNA-seq coverage from DNA sequence as a unifying model of gene regulation
Sequence-based machine-learning models trained on genomics data improve genetic
variant interpretation by providing functional predictions describing their impact on the cis …
variant interpretation by providing functional predictions describing their impact on the cis …
An integrated single cell and spatial transcriptomic map of human white adipose tissue
To date, single-cell studies of human white adipose tissue (WAT) have been based on small
cohort sizes and no cellular consensus nomenclature exists. Herein, we performed a …
cohort sizes and no cellular consensus nomenclature exists. Herein, we performed a …
Current sequence-based models capture gene expression determinants in promoters but mostly ignore distal enhancers
Background The largest sequence-based models of transcription control to date are
obtained by predicting genome-wide gene regulatory assays across the human genome …
obtained by predicting genome-wide gene regulatory assays across the human genome …
Update of the FANTOM web resource: expansion to provide additional transcriptome atlases
M Lizio, I Abugessaisa, S Noguchi, A Kondo… - Nucleic acids …, 2019 - academic.oup.com
The FANTOM web resource (http://fantom. gsc. riken. jp/) was developed to provide easy
access to the data produced by the FANTOM project. It contains the most complete and …
access to the data produced by the FANTOM project. It contains the most complete and …