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Roles of tumor-associated macrophages in anti-PD-1/PD-L1 immunotherapy for solid cancers
In recent years, tumor immunotherapy has made significant progress. However, tumor
immunotherapy, particularly immune checkpoint inhibitors (eg, PD-1/PD-L1 inhibitors) …
immunotherapy, particularly immune checkpoint inhibitors (eg, PD-1/PD-L1 inhibitors) …
Tumor-associated macrophages regulate PD-1/PD-L1 immunosuppression
Y Pu, Q Ji - Frontiers in immunology, 2022 - frontiersin.org
Anti-programmed cell death 1 (PD-1) or anti-PD-ligand (L) 1 drugs, as classic immune
checkpoint inhibitors, are considered promising treatment strategies for tumors. In clinical …
checkpoint inhibitors, are considered promising treatment strategies for tumors. In clinical …
Prostaglandin E2 in the tumor microenvironment, a convoluted affair mediated by EP receptors 2 and 4
The involvement of the prostaglandin E2 (PGE2) system in cancer progression has long
been recognized. PGE2 functions as an autocrine and paracrine signaling molecule with …
been recognized. PGE2 functions as an autocrine and paracrine signaling molecule with …
Arachidonate 15-lipoxygenase type B: Regulation, function, and its role in pathophysiology
As a lipoxygenase (LOX), arachidonate 15-lipoxygenase type B (ALOX15B) peroxidizes
polyenoic fatty acids (PUFAs) including arachidonic acid (AA), eicosapentaenoic acid (EPA) …
polyenoic fatty acids (PUFAs) including arachidonic acid (AA), eicosapentaenoic acid (EPA) …
ALOX5 promotes autophagy-dependent ferroptosis by activating the AMPK/mTOR pathway in melanoma
M Wang, G Zeng, B **ong, X Zhu, J Guo, D Chen… - Biochemical …, 2023 - Elsevier
Background Melanoma has become more common, and its therapeutic management has
remained challenging in recent decades. The purpose of our study is to explore new …
remained challenging in recent decades. The purpose of our study is to explore new …
Fatty acids metabolism affects the therapeutic effect of anti-PD-1/PD-L1 in tumor immune microenvironment in clear cell renal cell carcinoma
Background Clear cell renal cell carcinoma (ccRCC) is a highly invasive and metastatic
subtype of kidney malignancy and is correlated with metabolic reprogramming for …
subtype of kidney malignancy and is correlated with metabolic reprogramming for …
[HTML][HTML] Tumor associated macrophages transfer ceruloplasmin mRNA to fibrosarcoma cells and protect them from ferroptosis
Solid tumors are characterized by hypoxic areas, which are prone for macrophage
infiltration. Once infiltrated, macrophages polarize to tumor associated macrophages (TAM) …
infiltration. Once infiltrated, macrophages polarize to tumor associated macrophages (TAM) …
Tumor cell senescence-induced macrophage CD73 expression is a critical metabolic immune checkpoint in the aging tumor microenvironment
Background: The role of senescent cells in the tumor microenvironment (TME) is usually
bilateral, and diverse therapeutic approaches, such as radiotherapy and chemotherapy, can …
bilateral, and diverse therapeutic approaches, such as radiotherapy and chemotherapy, can …
Identification of the key genes and pathways involved in the tumorigenesis and prognosis of kidney renal clear cell carcinoma
Kidney renal clear cell carcinoma (KIRC) is the most common renal cell carcinoma (RCC).
However, patients with KIRC usually have poor prognosis due to limited biomarkers for early …
However, patients with KIRC usually have poor prognosis due to limited biomarkers for early …
Specialized pro-resolving mediators mitigate cancer-related inflammation: role of tumor-associated macrophages and therapeutic opportunities
M Lavy, V Gauttier, N Poirier, S Barillé-Nion… - Frontiers in …, 2021 - frontiersin.org
Inflammation is a fundamental physiological response orchestrated by innate immune cells
to restore tissue homeostasis. Specialized pro-resolving mediators (SPMs) are involved in …
to restore tissue homeostasis. Specialized pro-resolving mediators (SPMs) are involved in …