Wonders of tick saliva

PA Nuttall - Ticks and tick-borne diseases, 2019 - Elsevier
Saliva of ticks is arguably the most complex saliva of any animal. This is particularly the case
for ixodid species that feed for many days firmly attached to the same skin site of their …

[HTML][HTML] Cocktail anti-tick vaccines: the unforeseen constraints and approaches toward enhanced efficacies

C Ndawula Jr, AE Tabor - Vaccines, 2020 - mdpi.com
Ticks are second to mosquitoes as vectors of disease. Ticks affect livestock industries in
Asia, Africa and Australia at~ 1.13billionUSDperannum.Forinstance,80%oftheglobalcattlepopulationisatriskofinfestati …

Saliva proteome of partially-and fully-engorged adult female Haemaphysalis flava ticks

L Liu, R Cheng, S Mao, D Duan, L Feng, T Cheng - Veterinary Parasitology, 2023 - Elsevier
Tick saliva is a reservoir of bioactive proteins. Saliva protein compositions change
dynamically during blood-feeding. Decipherment of protein profiles in different blood …

Transcriptome analysis of Kunming mice responses to the bite of Xenopsylla cheopis

X Lun, Y Shi, Y Wang, N Zhao, Q Liu, F Meng… - Parasites & …, 2024 - Springer
Background Flea bites could trigger a series of complex molecular responses in the host.
However, our understanding of the responses at the molecular level is still relatively limited …

Amblyomma americanum serpin 27 (AAS27) is a tick salivary anti-inflammatory protein secreted into the host during feeding

L Tirloni, TK Kim, M Berger, C Termignoni… - PLoS neglected …, 2019 - journals.plos.org
Ticks successfully feed and transmit pathogens by injecting pharmacological compounds in
saliva to thwart host defenses. We have previously used LC-MS/MS to identify proteins that …

Rhipicephalus microplus serpins interfere with host immune responses by specifically modulating mast cells and lymphocytes

ML Coutinho, B Bizzarro, L Tirloni, M Berger… - Ticks and tick-borne …, 2020 - Elsevier
Rhipicephalus microplus ticks feed on a bovine host for three weeks. At the attachment site,
inflammatory and immune responses are triggered resulting in the recruitment of cells and …

Amblyomma americanum serpin 41 (AAS41) inhibits inflammation by targeting chymase and chymotrypsin

TK Kim, L Tirloni, M Berger, JK Diedrich… - International journal of …, 2020 - Elsevier
Ticks inject serine protease inhibitors (serpins) into their feeding sites to evade serine
protease-mediated host defenses against tick-feeding. This study describes two highly …

Amblyomma americanum ticks utilizes countervailing pro and anti-inflammatory proteins to evade host defense

M Bakshi, TK Kim, L Porter, W Mwangi… - PLoS …, 2019 - journals.plos.org
Feeding and transmission of tick-borne disease (TBD) agents by ticks are facilitated by tick
saliva proteins (TSP). Thus, defining functional roles of TSPs in tick evasion is expected to …

[HTML][HTML] The Immunomodulatory Effect of IrSPI, a Tick Salivary Gland Serine Protease Inhibitor Involved in Ixodes ricinus Tick Feeding

AA Blisnick, L Šimo, C Grillon, F Fasani, S Brûlé… - Vaccines, 2019 - mdpi.com
Ticks are the most important vectors of pathogens affecting both domestic and wild animals
worldwide. Hard tick feeding is a slow process—taking up to several days—and …

A microRNA profile of saliva and the role of miR-375 in Haemaphysalis longicornis (Ixodida: Ixodidae)

MI Malik, M Nawaz, IA Hassan, H Zhang, H Gong… - Parasites & …, 2019 - Springer
Background Tick saliva contains many bioactive molecules that are involved in attachment
to the host, blood-feeding and transmission of pathogens. MicroRNAs (miRNAs) are a class …