Cells respond to intrinsic and extrinsic stresses by reducing global protein synthesis and
activating gene programs necessary for survival. Here, we show that the integrated stress …

RNA molecules are important players in all domains of life and the study of the relationship
between their multiple flexible states and the associated biological roles has increased in …

Shutoff of global protein synthesis is a conserved response to cellular stresses. This general
phenomenon is accompanied by the induction of distinct gene programs tailored to each …

To generate infectious virus, HIV-1 must package two copies of its full-length RNA into
particles. HIV-1 transcription initiates from multiple, neighboring sites, generating RNA …

RNA molecules are key players in a variety of biological events, and this is particularly true
for viral RNAs. To better understand the replication of those pathogens and try to block them …

The encephalomyocarditis virus internal ribosome entry site (EMCV IRES) is a structured
RNA sequence found in the 5′ UTR of the genomic RNA of the encephalomyocarditis virus …

Abstract 5′ Cap structures are ubiquitous on eukaryotic mRNAs, essential for post-
transcriptional processing, translation initiation and stability. Here we describe a biosensor …

High‐resolution mass spectrometry was used for the label‐free, direct localization and
relative quantification of CMC+‐modifications of a neomycin‐sensing riboswitch aptamer …

The recent identification and development of RNA-guided enzymes for programmable
cleavage of target nucleic acids offers exciting possibilities for both therapeutic and …

RNAs adopt specific structures to perform their functions, which are critical to fundamental
cellular processes. For decades, these structures have been determined and modeled with …