TGF-β suppresses type 2 immunity to cancer

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[HTML][HTML] TGF-β signaling in health and disease

J Massagué, D Sheppard - Cell, 2023 - cell.com
The TGF-β regulatory system plays crucial roles in the preservation of organismal integrity.
TGF-β signaling controls metazoan embryo development, tissue homeostasis, and injury …
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The hallmarks of cancer immune evasion

C Galassi, TA Chan, I Vitale, L Galluzzi - Cancer Cell, 2024 - cell.com
According to the widely accepted" three Es" model, the host immune system eliminates
malignant cell precursors and contains microscopic neoplasms in a dynamic equilibrium …
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Overcoming TGFβ-mediated immune evasion in cancer

DVF Tauriello, E Sancho, E Batlle - Nature Reviews Cancer, 2022 - nature.com
Transforming growth factor-β (TGFβ) signalling controls multiple cell fate decisions during
development and tissue homeostasis; hence, dysregulation of this pathway can drive …
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Spatial architecture of the immune microenvironment orchestrates tumor immunity and therapeutic response

T Fu, LJ Dai, SY Wu, Y ** circuits in …
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[HTML][HTML] The type 2 cytokine Fc–IL-4 revitalizes exhausted CD8+ T cells against cancer

B Feng, Z Bai, X Zhou, Y Zhao, YQ **e, X Huang, Y Liu… - Nature, 2024 - nature.com
Current cancer immunotherapy predominately focuses on eliciting type 1 immune responses
fighting cancer; however, long-term complete remission remains uncommon,. A pivotal …
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