The alarmin cytokines thymic stromal lymphopoietin (TSLP), interleukin (IL)‐33, and IL‐25
are epithelial cell‐derived mediators that contribute to the pathobiology and …

Eosinophilic esophagitis (EoE) is a chronic inflammatory disease characterized by
eosinophilic infiltration of the esophagus. It arises from a complex interplay of genetic …

While both the incidence and general awareness of food allergies is increasing, the variety
and clinical availability of therapeutics remain limited. Therefore, investigations into the …

The increased risk of food allergy in infants with atopic dermatitis has long been recognized;
an epidemiologic phenomenon termed “the atopic march.” Current literature supports the …

Abstract Purpose of Review Compelling evidence over the past decade supports the central
role of epithelial barrier dysfunction in the pathophysiology of eosinophilic esophagitis …

Background Eosinophilic esophagitis (EoE) is an increasingly common inflammatory
condition of the esophagus; however, the underlying immunologic mechanisms remain …

Dupilumab is a monoclonal antibody targeting interleukin-4 and interleukin-13, approved for
the treatment of multiple T2 diseases and more recently for Eosinophilic Esophagitis (EoE) …

In this review, we provide an overview of food allergy genetics and epigenetics aimed at
clinicians and researchers. This includes a brief review of the current understanding of …

Rationale Eosinophilic gastrointestinal disorders (EGID), including eosinophilic esophagitis
(EoE), are inflammatory disorders of the gastrointestinal mucosa mediated by complex …

Primary atopic disorders are a group of inborn errors of immunity that skew the immune
system toward severe allergic disease. Defining the biology underlying these extreme …