Monogenic diabetes includes several clinical conditions generally characterized by early-
onset diabetes, such as neonatal diabetes, maturity-onset diabetes of the young (MODY) …

Background Wolfram syndrome (WS), a rare genetic disorder, is considered the best
prototype of endoplasmic reticulum (ER) diseases. Classical WS features are childhood …

Organelles cooperate with each other to control cellular homeostasis and cell functions by
forming close connections through membrane contact sites. Important contacts are present …

Wolfram syndrome is a rare genetic disease caused by mutations in the WFS1 or CISD2
gene. A primary defect in Wolfram syndrome involves poor ER Ca2+ handling, but how this …

It has become apparent that our textbook illustration of singular isolated organelles is
obsolete. In reality, organelles form complex cooperative networks involving various types of …

NEET proteins belong to a highly conserved group of [2Fe–2S] proteins found across all
kingdoms of life. Due to their unique [2Fesingle bond2S] cluster structure, they play a key …

Abstract Wolfram syndrome 1 (WS1) is a rare autosomal recessive neurodegenerative
disease characterized by diabetes insipidus, diabetes mellitus, optic atrophy, deafness, and …

Abstract The CISD2 (NAF-1) protein plays a key role in regulating cellular homeostasis,
aging, cancer and neurodegenerative diseases. It was found to control different calcium …

Calcium ions (Ca2+) operate as important messengers in the cell, indispensable for
signaling the underlying numerous cellular processes in all of the cell types in the human …

Wolfram syndrome (WS) is a recessive multisystem disorder defined by the association of
diabetes mellitus and optic atrophy, reminiscent of mitochondrial diseases. The role played …