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Lipid nanoparticle (LNP) enables mRNA delivery for cancer therapy
Messenger RNA (mRNA) has received great attention in the prevention and treatment of
various diseases due to the success of coronavirus disease 2019 (COVID‐19) mRNA …
various diseases due to the success of coronavirus disease 2019 (COVID‐19) mRNA …
[HTML][HTML] Role of lipid-based and polymer-based non-viral vectors in nucleic acid delivery for next-generation gene therapy
The field of gene therapy has experienced an insurgence of attention for its widespread
ability to regulate gene expression by targeting genomic DNA, messenger RNA, microRNA …
ability to regulate gene expression by targeting genomic DNA, messenger RNA, microRNA …
Polymer nanoparticles deliver mRNA to the lung for mucosal vaccination
An inhalable platform for messenger RNA (mRNA) therapeutics would enable minimally
invasive and lung-targeted delivery for a host of pulmonary diseases. Development of lung …
invasive and lung-targeted delivery for a host of pulmonary diseases. Development of lung …
Unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has
highlighted the need for vaccines that not only prevent disease but also prevent …
highlighted the need for vaccines that not only prevent disease but also prevent …
A biodegradable iridium (III) coordination polymer for enhanced two‐photon photodynamic therapy using an apoptosis–ferroptosis hybrid pathway
L Ke, F Wei, L ** the endosome: assessing cellular trafficking mechanisms of non-viral vehicles
E Xu, WM Saltzman, AS Piotrowski-Daspit - Journal of Controlled Release, 2021 - Elsevier
Non-viral vehicles hold therapeutic promise in advancing the delivery of a variety of cargos
in vitro and in vivo, including small molecule drugs, biologics, and especially nucleic acids …
in vitro and in vivo, including small molecule drugs, biologics, and especially nucleic acids …
Smart polymeric nanoparticles in cancer immunotherapy
Z Yu, X Shen, H Yu, H Tu, C Chittasupho, Y Zhao - Pharmaceutics, 2023 - mdpi.com
Cancer develops with unexpected mutations and causes death in many patients. Among the
different cancer treatment strategies, immunotherapy is promising with the benefits of high …
different cancer treatment strategies, immunotherapy is promising with the benefits of high …
Polymeric vehicles for nucleic acid delivery
AS Piotrowski-Daspit, AC Kauffman… - Advanced drug delivery …, 2020 - Elsevier
Polymeric vehicles are versatile tools for therapeutic gene delivery. Many polymers—when
assembled with nucleic acids into vehicles—can protect the cargo from degradation and …
assembled with nucleic acids into vehicles—can protect the cargo from degradation and …