HPV+ head and neck cancer–derived small extracellular vesicles communicate with TRPV1+ neurons to mediate cancer pain

KE Inyang, CM Evans, M Heussner, M Petroff… - Pain, 2024 - journals.lww.com
Severe pain is often experienced by patients with head and neck cancer and is associated
with a poor prognosis. Despite its frequency and severity, current treatments fail to …

The µ-δ opioid heteromer masks latent pain sensitization in neuropathic and inflammatory pain in male and female mice

KE Inyang, SR George, G Laumet - Brain Research, 2021 - Elsevier
The episodic nature of chronic pain can be studied in the rodent model of latent pain
sensitization. After remission, central sensitization is opposed by activation of opioid …

Tonic Meningeal Interleukin-10 Upregulates Delta Opioid Receptor to Prevent Relapse to Pain

KE Inyang, J Sim, KB Clark, G Matan, K Monahan… - bioRxiv, 2023 - biorxiv.org
Chronic pain often alternates between transient remission and relapse of severe pain. While
most research on chronic pain has focused on mechanisms maintaining pain, there is a …

Head and Neck Cancer-derived small extracellular vesicles sensitize TRPV1+ neurons to mediate cancer pain

KE Inyang, CM Evans, M Heussner, M Petroff… - bioRxiv, 2022 - biorxiv.org
Severe pain is often experienced by patients with head and neck cancer and is associated
with a poor prognosis. Despite its frequency and severity, current treatments fail to …

[BOOK][B] The Role of AMPK Activation in the Attenuation of Chronic Pain

K Inyang - 2019 - search.proquest.com
Chronic pain is a serious medical condition that impacts over 100 million Americans each
year. Metformin is a widely prescribed drug used in the treatment of type II diabetes that has …