Talin has emerged as the key cytoplasmic protein that mediates integrin adhesion to the
extracellular matrix. In this Review, we draw on experiments performed in mammalian cells …

Integrin receptors provide a dynamic, tightly-regulated link between the extracellular matrix
(or cellular counter-receptors) and intracellular cytoskeletal and signalling networks …

Mechanical forces are central to developmental, physiological and pathological processes.
However, limited understanding of force transmission within sub-cellular structures is a …

Fluorescence microscopy provides an efficient and unique approach to study fixed and
living cells because of its versatility, specificity, and high sensitivity. Fluorescence …

Clostridioides difficile spores produced during infection are important for the recurrence of
the disease. Here, we show that C. difficile spores gain entry into the intestinal mucosa via …

Integrins in focal adhesions (FAs) mediate adhesion and force transmission to extracellular
matrices essential for cell motility, proliferation and differentiation. Different fibronectin …

Cells govern tissue shape by exerting highly regulated forces at sites of matrix adhesion. As
the major force-bearing adhesion-receptor protein, integrins have a central role in how cells …

Interaction of cells with the extracellular matrix is fundamental to a wide variety of biological
processes, such as cell proliferation, cell migration, embryogenesis, and organization of …

Regulated activation of integrins is critical for cell adhesion, motility and tissue homeostasis.
Talin and kindlins activate β1-integrins, but the counteracting inhibiting mechanisms are …

Interactions between dynamic microtubules and actin filaments (F-actin) underlie a range of
cellular processes including cell polarity and motility. In growth cones, dynamic microtubules …