Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants
Depression is a common, devastating illness. Current pharmacotherapies help many
patients, but high rates of a partial response or no response, and the delayed onset of the …
patients, but high rates of a partial response or no response, and the delayed onset of the …
Sleep and the price of plasticity: from synaptic and cellular homeostasis to memory consolidation and integration
Sleep is universal, tightly regulated, and its loss impairs cognition. But why does the brain
need to disconnect from the environment for hours every day? The synaptic homeostasis …
need to disconnect from the environment for hours every day? The synaptic homeostasis …
Glutamate receptor ion channels: structure, regulation, and function
The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
The AMPA receptor code of synaptic plasticity
Changes in the properties and postsynaptic abundance of AMPA-type glutamate receptors
(AMPARs) are major mechanisms underlying various forms of synaptic plasticity, including …
(AMPARs) are major mechanisms underlying various forms of synaptic plasticity, including …
[HTML][HTML] The molecular and systems biology of memory
ER Kandel, Y Dudai, MR Mayford - Cell, 2014 - cell.com
Learning and memory are two of the most magical capabilities of our mind. Learning is the
biological process of acquiring new knowledge about the world, and memory is the process …
biological process of acquiring new knowledge about the world, and memory is the process …
AMPARs and synaptic plasticity: the last 25 years
RL Huganir, RA Nicoll - Neuron, 2013 - cell.com
The study of synaptic plasticity and specifically LTP and LTD is one of the most active areas
of research in neuroscience. In the last 25 years we have come a long way in our …
of research in neuroscience. In the last 25 years we have come a long way in our …
Neurotoxicity of amyloid β-protein: synaptic and network dysfunction
Evidence for an ever-expanding variety of molecular mediators of amyloid β-protein
neurotoxicity (membrane lipids, receptor proteins, channel proteins, second messengers …
neurotoxicity (membrane lipids, receptor proteins, channel proteins, second messengers …
Endocytosis and signalling: intertwining molecular networks
A Sorkin, M Von Zastrow - Nature reviews Molecular cell biology, 2009 - nature.com
Cell signalling and endocytic membrane trafficking have traditionally been viewed as distinct
processes. Although our present understanding is incomplete and there are still great …
processes. Although our present understanding is incomplete and there are still great …
Plastic synaptic networks of the amygdala for the acquisition, expression, and extinction of conditioned fear
HC Pape, D Pare - Physiological reviews, 2010 - journals.physiology.org
The last 10 years have witnessed a surge of interest for the mechanisms underlying the
acquisition and extinction of classically conditioned fear responses. In part, this results from …
acquisition and extinction of classically conditioned fear responses. In part, this results from …
Hippocampal synaptic plasticity, spatial memory and anxiety
Recent studies using transgenic mice lacking NMDA receptors in the hippocampus
challenge the long-standing hypothesis that hippocampal long-term potentiation-like …
challenge the long-standing hypothesis that hippocampal long-term potentiation-like …