Engineers are torn between an attitude of strong design and dreams of autonomous
devices. They want full mastery of their artifacts while wishing these were much more …

Understanding how the genome instructs the phenotypic characteristics of an organism is
one of the major scientific endeavors of our time. Advances in genetics have progressively …

The study of multicellular development is grounded in two complementary domains: cell
biomechanics, which examines how physical forces shape the embryo, and genetic …

The transition state model of cell differentiation proposes that a transient window of gene
expression stochasticity precedes entry into a differentiated state. Here, we assess this …

During early Drosophila embryogenesis, a network of gene regulatory interactions
orchestrates terminal patterning, playing a critical role in the subsequent formation of the gut …

The growing availability of imaging data, calculation power, and algorithm sophistication are
transforming the study of morphogenesis into a computation-driven discipline. In parallel, it …

The registration, segmentation, and annotation of microscopy images and respective
biological objects (eg, cells) are distinct challenges often encountered in bioimage …

During morphogenesis, embryonic tissues display fluid-like behavior with fluctuating strain
rates. Digital cell lineages reconstructed from 4D images of develo** zebrafish embryos …

Large sets of elements interacting locally and producing specific architectures reliably form a
category that transcends the usual dividing line between biological and engineered …

We conducted a quantitative comparison of develo** sea urchin embryos based on the
analysis of five digital specimens obtained by automatic processing of in toto 3D+ time …