BACKGROUND Liquid biopsies that are based on analysis of cell-free DNA from plasma
offer diagnostic information that is otherwise accessible conventionally through invasive …

Preeclampsia is a leading cause of maternal and fetal/neonatal mortality and morbidity
worldwide. The early identification of patients with an increased risk for preeclampsia is …

Cell-free fetal DNA is present in the plasma of pregnant women. It consists of short DNA
fragments among primarily maternally derived DNA fragments. We sequenced a maternal …

Chromosomal aneuploidy is the major reason why couples opt for prenatal diagnosis.
Current methods for definitive diagnosis rely on invasive procedures, such as chorionic …

Noninvasive prenatal testing using fetal DNA in maternal plasma is an actively researched
area. The current generation of tests using massively parallel sequencing is based on …

Background: The discovery of circulating fetal nucleic acids in maternal plasma has opened
up new possibilities for noninvasive prenatal diagnosis. MicroRNAs (miRNAs), a class of …

Trisomy 21 is the most common reason that women opt for prenatal diagnosis. Conventional
prenatal diagnostic methods involve the sampling of fetal materials by invasive procedures …

Prenatal diagnosis of monogenic diseases, such as cystic fibrosis and β-thalassemia, is
currently offered as part of public health programs. However, current methods based on …

In the field of circulating cell-free DNA, most of the studies have focused on short DNA
molecules (eg,< 500 bp). The existence of long cell-free DNA molecules has been poorly …

Embodiments of this invention provide methods, systems, and apparatus for determining
whether a fetal chromosomal aneuploidy exists from a biological sample obtained from a …