The tumour microenvironment (TME) highly influences the growth and spread of tumours,
thus impacting the patient's clinical outcome. In this context, the complement system plays a …

Under cell stress, global protein synthesis is inhibited to preserve energy. One mechanism is
to sequester and silence mRNAs in ribonucleoprotein complexes known as stress granules …

The core cohesin subunit STAG2 is recurrently mutated in Ewing sarcoma but its biological
role is less clear. Here, we demonstrate that cohesin complexes containing STAG2 occupy …

For decades, the complement system, the central pillar of innate immune response, was
recognized as a protective mechanism against cancer cells and the manipulation of …

The CCCTC-binding factor (CTCF), which anchors DNA loops that organize the genome into
structural domains, has a central role in gene control by facilitating or constraining …

Somatic mutations contribute to tumorigenesis. Although these mutations occur in all
proliferating cells, their accumulation under non-malignant conditions, such as in …

ABSTRACT Ewing´ s Sarcoma Family of Tumors (ESFT) are clinically aggressive bone and
soft tissue tumors in children and young adults. Analysis of the immune tumor …

EWS/ETS fusion transcription factors, most commonly EWSR1:: FLI1, drives initiation and
progression of Ewing sarcoma (EwS). Even though direct targeting EWSR1:: FLI1 is a …

Ewing sarcoma is an undifferentiated small-round-cell sarcoma. Although molecular
detection of pathognomonic EWSR1-ETS fusions such as EWSR1-FLI1 enables definitive …

Purpose: SLFN11 was identified as a critical determinant of response to DNA-targeted
therapies by analyzing gene expression and drug sensitivity of NCI-60 and CCLE datasets …