Aging is characterized by systemic chronic inflammation, which is accompanied by cellular
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …

Background Recently, the hallmarks of aging were updated to include dysbiosis, disabled
macroautophagy, and chronic inflammation. In particular, the low-grade chronic …

Ageing organisms accumulate senescent cells that are thought to contribute to body
dysfunction. Telomere shortening and damage are recognized causes of cellular …

Nuclear factor κB (NF-κB) is a dimeric transcription factor constituted by two of five protein
family members. It plays an essential role in inflammation and immunity by regulating the …

Reactive oxygen species (ROS) are bioproducts of cellular metabolism. There is a range of
molecules with oxidizing properties known as ROS. Despite those molecules being implied …

Although cellular senescence drives multiple age-related co-morbidities through the
senescence-associated secretory phenotype, in vivo senescent cell identification remains …

Cellular senescence is a cell fate triggered in response to stress and is characterized by
stable cell-cycle arrest and a hypersecretory state. It has diverse biological roles, ranging …

Periodontal disease is classically characterized by progressive destruction of the soft and
hard tissues of the periodontal complex, mediated by an interplay between dysbiotic …

While many diseases of aging have been linked to the immunological system, immune
metrics capable of identifying the most at-risk individuals are lacking. From the blood …

Inflammation is a biological response involving immune cells, blood vessels and mediators
induced by endogenous and exogenous stimuli, such as pathogens, damaged cells or …