Fine-map** genetic associations
Whilst thousands of genetic variants have been associated with human traits, identifying the
subset of those variants that are causal requires a further 'fine-map**'step. We review the …
subset of those variants that are causal requires a further 'fine-map**'step. We review the …
Genetic basis of lacunar stroke: a pooled analysis of individual patient data and genome-wide association studies
M Traylor, E Persyn, L Tomppo, S Klasson… - The Lancet …, 2021 - thelancet.com
Background The genetic basis of lacunar stroke is poorly understood, with a single locus on
16q24 identified to date. We sought to identify novel associations and provide mechanistic …
16q24 identified to date. We sought to identify novel associations and provide mechanistic …
The goldmine of GWAS summary statistics: a systematic review of methods and tools
Genome-wide association studies (GWAS) have revolutionized our understanding of the
genetic architecture of complex traits and diseases. GWAS summary statistics have become …
genetic architecture of complex traits and diseases. GWAS summary statistics have become …
Assessing digital phenoty** to enhance genetic studies of human diseases
Population-scale biobanks that combine genetic data and high-dimensional phenoty** for
a large number of participants provide an exciting opportunity to perform genome-wide …
a large number of participants provide an exciting opportunity to perform genome-wide …
A flexible empirical Bayes approach to multivariate multiple regression, and its improved accuracy in predicting multi-tissue gene expression from genotypes
Predicting phenotypes from genotypes is a fundamental task in quantitative genetics. With
technological advances, it is now possible to measure multiple phenotypes in large …
technological advances, it is now possible to measure multiple phenotypes in large …
Harnessing genomic analysis to explore the role of telomeres in the pathogenesis and progression of diabetic kidney disease
The prevalence of diabetes is increasing globally, and this trend is predicted to continue for
future decades. Research is needed to uncover new ways to manage diabetes and its co …
future decades. Research is needed to uncover new ways to manage diabetes and its co …
Enrichment analyses identify shared associations for 25 quantitative traits in over 600,000 individuals from seven diverse ancestries
Summary Since 2005, genome-wide association (GWA) datasets have been largely biased
toward sampling European ancestry individuals, and recent studies have shown that GWA …
toward sampling European ancestry individuals, and recent studies have shown that GWA …
Improved methods for empirical Bayes multivariate multiple testing and effect size estimation
Estimating the sharing of genetic effects across different conditions is important to many
statistical analyses of genomic data. The patterns of sharing arising from these data are …
statistical analyses of genomic data. The patterns of sharing arising from these data are …
Combining genome-wide studies of breast, prostate, ovarian and endometrial cancers maps cross-cancer susceptibility loci and identifies new genetic associations
We report a meta-analysis of breast, prostate, ovarian, and endometrial cancer genome-
wide association data (effective sample size: 237,483 cases/317,006 controls). This …
wide association data (effective sample size: 237,483 cases/317,006 controls). This …
Characterizing common and rare variations in non-traditional glycemic biomarkers using multivariate approaches on multi-ancestry ARIC study
Genetic studies of non-traditional glycemic biomarkers, glycated albumin and fructosamine,
can shed light on unknown aspects of type 2 diabetes genetics and biology. We performed a …
can shed light on unknown aspects of type 2 diabetes genetics and biology. We performed a …