BCL-2 family proteins, which have either pro-or anti-apoptotic activities, have been studied
intensively for the past decade owing to their importance in the regulation of apoptosis …

Apoptosis, the cell-suicide programme executed by caspases, is critical for maintaining
tissue homeostasis, and impaired apoptosis is now recognized to be a key step in …

A common feature of follicular lymphoma, the most prevalent haematological malignancy in
humans, is a chromosome translocation (t (14; 18)) that has coupled the immunoglobulin …

Apoptosis is initiated when Bcl-2 and its prosurvival relatives are engaged by proapoptotic
BH3-only proteins via interaction of its BH3 domain with a groove on the Bcl-2-like proteins …

The Bcl-2 family of proteins controls a critical step in commitment to apoptosis by regulating
permeabilization of the mitochondrial outer membrane (MOM). The family is divided into …

Commitment of cells to apoptosis is governed largely by the interaction between members of
the Bcl-2 protein family. Its three subfamilies have distinct roles: The BH3-only proteins …

A central issue in the regulation of apoptosis by the Bcl-2 family is whether its BH3-only
members initiate apoptosis by directly binding to the essential cell-death mediators Bax and …

The central role of the Bcl-2 family in regulating apoptotic cell death was first identified in the
1980s. Since then, significant in-roads have been made in identifying the multiple members …

Intrinsic apoptosis, the response to intracellular cell death stimuli, is regulated by the
interplay of the B-cell lymphoma 2 (Bcl-2) family and their membrane interactions. Bcl-2 …

Retinal ganglion cell (RGC) death is the principal consequence of injury to the optic nerve.
For several decades, we have understood that the RGC death process was executed by …