[HTML][HTML] Rheumatoid arthritis: a brief overview of the treatment
Rheumatoid arthritis (RA) is a chronic, inflammatory, systemic autoimmune disease,
affecting the joints with varying severity among patients. The risk factors include age …
affecting the joints with varying severity among patients. The risk factors include age …
Biomechanics of aortic wall failure with a focus on dissection and aneurysm: A review
Aortic dissections and aortic aneurysms are fatal events characterized by structural changes
to the aortic wall. The maximum diameter criterion, typically used for aneurysm rupture risk …
to the aortic wall. The maximum diameter criterion, typically used for aneurysm rupture risk …
Smad7 effects on TGF-β and ErbB2 restrain myofibroblast activation and protect from postinfarction heart failure
Repair of the infarcted heart requires TGF-β/Smad3 signaling in cardiac myofibroblasts.
However, TGF-β–driven myofibroblast activation needs to be tightly regulated in order to …
However, TGF-β–driven myofibroblast activation needs to be tightly regulated in order to …
The chemistry and biology of collagen hybridization
X Li, Q Zhang, SM Yu, Y Li - Journal of the American Chemical …, 2023 - ACS Publications
Collagen provides mechanical and biological support for virtually all human tissues in the
extracellular matrix (ECM). Its defining molecular structure, the triple-helix, could be …
extracellular matrix (ECM). Its defining molecular structure, the triple-helix, could be …
Accumulation of collagen molecular unfolding is the mechanism of cyclic fatigue damage and failure in collagenous tissues
Overuse injuries to dense collagenous tissues are common, but their etiology is poorly
understood. The predominant hypothesis that micro-damage accumulation exceeds the rate …
understood. The predominant hypothesis that micro-damage accumulation exceeds the rate …
Mechanochemistry of collagen
The collagen molecular family is the result of nearly one billion years of evolution. It is a
unique family of proteins, the majority of which provide general mechanical support to …
unique family of proteins, the majority of which provide general mechanical support to …
Protective effects of activated myofibroblasts in the pressure-overloaded myocardium are mediated through smad-dependent activation of a matrix-preserving program
Rationale: The heart contains abundant interstitial and perivascular fibroblasts. Traditional
views suggest that, under conditions of mechanical stress, cytokines, growth factors, and …
views suggest that, under conditions of mechanical stress, cytokines, growth factors, and …
Mechanics and structural stability of the collagen triple helix
MWH Kirkness, K Lehmann, NR Forde - Current opinion in chemical …, 2019 - Elsevier
The primary building block of the body is collagen, which is found in the extracellular matrix
and in many stress-bearing tissues such as tendon and cartilage. It provides elasticity and …
and in many stress-bearing tissues such as tendon and cartilage. It provides elasticity and …
[HTML][HTML] Mechanics of isolated individual collagen fibrils
Collagen fibrils are the fundamental structural elements in vertebrate animals and compose
a structural framework that provides mechanical support to load-bearing tissues …
a structural framework that provides mechanical support to load-bearing tissues …
Terminal repeats impact collagen triple-helix stability through hydrogen bonding
Nearly 30% of human proteins have tandem repeating sequences. Structural understanding
of the terminal repeats is well-established for many repeat proteins with the common α-helix …
of the terminal repeats is well-established for many repeat proteins with the common α-helix …