The global health burden of human tuberculosis (TB) and the widespread antibiotic
resistance of its causative agent Mycobacterium tuberculosis warrant new strategies for TB …

The causative agent of tuberculosis (TB), Mycobacterium tuberculosis, infects one-third of
the world population. TB remains the leading cause of mortality due to a single bacterial …

The first edition of Molecular Genetics of Mycobacteria (1) was published very shortly after
the release of the complete genome sequence of Mycobacterium tuberculosis H37Rv (2) …

Background Increasing resistance to anti-tuberculosis drugs has driven the need for
develo** new drugs. Resources such as the tropical disease research (TDR) target …

Abstract Nucleoside Monophosphate Kinases (NMPKs) family are key enzymes in
nucleotide metabolism. Bacterial UMPKs depart from the main superfamily of NMPKs …

Objectives To develop a new one-pot polyphosphate kinase (PPK) system with low cost and
high efficiency for ATP regeneration in industrial CTP production. Results We developed a …

The pyrH-encoded uridine 5′-monophosphate kinase (UMPK) is involved in both de novo
and salvage synthesis of DNA and RNA precursors. Here we describe Mycobacterium …

The need for new antibiotics has become pressing in light of the emergence of antibiotic-
resistant strains of human pathogens. Yersinia pestis, the causative agent of plague, is a …

Mycobacterium is acid fast genus of bacteria that include many pathogenic and non
pathogenic species. Treatment is made quite difficult by the presence of metabolically silent …

Every year, Mycobacterium tuberculosis (Mtb), the causative agent of the disease
tuberculosis kills nearly two million people globally. In recent times this public health …