Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine
The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
Unstructural biology of TRP ion channels: the role of intrinsically disordered regions in channel function and regulation
B Goretzki, C Guhl, F Tebbe, JM Harder… - Journal of Molecular …, 2021 - Elsevier
The first genuine high-resolution single particle cryo-electron microscopy structure of a
membrane protein determined was a transient receptor potential (TRP) ion channel, TRPV1 …
membrane protein determined was a transient receptor potential (TRP) ion channel, TRPV1 …
Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling
G protein-coupled receptors of nociceptive neurons can sensitize transient receptor potential
(TRP) ion channels, which amplify neurogenic inflammation and pain. Protease-activated …
(TRP) ion channels, which amplify neurogenic inflammation and pain. Protease-activated …
Modulation of neuroinflammation: role and therapeutic potential of TRPV1 in the neuro-immune axis
WL Kong, YY Peng, BW Peng - Brain, behavior, and immunity, 2017 - Elsevier
Transient receptor potential vanilloid type 1 channel (TRPV1), as a ligand-gated non-
selective cation channel, has recently been demonstrated to have wide expression in the …
selective cation channel, has recently been demonstrated to have wide expression in the …
[HTML][HTML] Conjugated polymers mediate intracellular Ca2+ signals in circulating endothelial colony forming cells through the reactive oxygen species-dependent …
Endothelial colony forming cells (ECFCs) represent the most suitable cellular substrate to
induce revascularization of ischemic tissues. Recently, optical excitation of the light-sensitive …
induce revascularization of ischemic tissues. Recently, optical excitation of the light-sensitive …
TRPV1 channels and the progesterone receptor Sig-1R interact to regulate pain
M Ortíz-Rentería, R Juárez-Contreras… - Proceedings of the …, 2018 - National Acad Sciences
The Transient Receptor Potential Vanilloid 1 (TRPV1) ion channel is expressed in
nociceptors where, when activated by chemical or thermal stimuli, it functions as an …
nociceptors where, when activated by chemical or thermal stimuli, it functions as an …
[HTML][HTML] Neuropathic pain in a Fabry disease rat model
Fabry disease, the most common lysosomal storage disease, affects multiple organs and
results in a shortened life span. This disease is caused by a deficiency of the lysosomal …
results in a shortened life span. This disease is caused by a deficiency of the lysosomal …
Pharmacology of the capsaicin receptor, transient receptor potential vanilloid type-1 ion channel
The capsaicin receptor, transient receptor potential vanilloid type 1 ion channel (TRPV1),
has been identified as a polymodal transducer molecule on a sub-set of primary sensory …
has been identified as a polymodal transducer molecule on a sub-set of primary sensory …
ΔN-TRPV1: a molecular co-detector of body temperature and osmotic stress
Thirst and antidiuretic hormone secretion occur during hyperthermia or hypertonicity to
preserve body hydration. These vital responses are triggered when hypothalamic …
preserve body hydration. These vital responses are triggered when hypothalamic …
N-glycosylation in regulation of the nervous system
Protein N-glycosylation can influence the nervous system in a variety of ways by affecting
functions of glycoproteins involved in nervous system development and physiology. The …
functions of glycoproteins involved in nervous system development and physiology. The …