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Store-operated calcium channels
M Prakriya, RS Lewis - Physiological reviews, 2015 - journals.physiology.org
Store-operated calcium channels (SOCs) are a major pathway for calcium signaling in
virtually all metozoan cells and serve a wide variety of functions ranging from gene …
virtually all metozoan cells and serve a wide variety of functions ranging from gene …
Diseases caused by mutations in ORAI1 and STIM1
Ca2+ release‐activated Ca2+ (CRAC) channels mediate a specific form of Ca2+ influx
called store‐operated Ca2+ entry (SOCE) that contributes to the function of many cell types …
called store‐operated Ca2+ entry (SOCE) that contributes to the function of many cell types …
STIM proteins: dynamic calcium signal transducers
J Soboloff, BS Rothberg, M Madesh… - Nature reviews Molecular …, 2012 - nature.com
Stromal interaction molecule (STIM) proteins function in cells as dynamic coordinators of
cellular calcium (Ca2+) signals. Spanning the endoplasmic reticulum (ER) membrane, they …
cellular calcium (Ca2+) signals. Spanning the endoplasmic reticulum (ER) membrane, they …
Crystal structure of the calcium release–activated calcium channel Orai
X Hou, L Pedi, MM Diver, SB Long - Science, 2012 - science.org
The plasma membrane protein Orai forms the pore of the calcium release–activated calcium
(CRAC) channel and generates sustained cytosolic calcium signals when triggered by …
(CRAC) channel and generates sustained cytosolic calcium signals when triggered by …
[HTML][HTML] Organization and function of membrane contact sites
SCJ Helle, G Kanfer, K Kolar, A Lang, AH Michel… - … et Biophysica Acta (BBA …, 2013 - Elsevier
Membrane-bound organelles are a wonderful evolutionary acquisition of the eukaryotic cell,
allowing the segregation of sometimes incompatible biochemical reactions into specific …
allowing the segregation of sometimes incompatible biochemical reactions into specific …
Store-operated calcium entry: Mechanisms and modulation
PG Hogan, A Rao - Biochemical and biophysical research communications, 2015 - Elsevier
Store-operated calcium entry is a central mechanism in cellular calcium signalling and in
maintaining cellular calcium balance. This review traces the history of research on store …
maintaining cellular calcium balance. This review traces the history of research on store …
Mechanosensing drives acuity of αβ T-cell recognition
T lymphocytes use surface α β T-cell receptors (TCRs) to recognize peptides bound to MHC
molecules (pMHCs) on antigen-presenting cells (APCs). How the exquisite specificity of high …
molecules (pMHCs) on antigen-presenting cells (APCs). How the exquisite specificity of high …
Circularly permuted LOV2 as a modular photoswitch for optogenetic engineering
Plant-based photosensors, such as the light-oxygen-voltage sensing domain 2 (LOV2) from
oat phototropin 1, can be modularly wired into cell signaling networks to remotely control …
oat phototropin 1, can be modularly wired into cell signaling networks to remotely control …
Near-infrared photoactivatable control of Ca2+ signaling and optogenetic immunomodulation
The application of current channelrhodopsin-based optogenetic tools is limited by the lack of
strict ion selectivity and the inability to extend the spectra sensitivity into the near-infrared …
strict ion selectivity and the inability to extend the spectra sensitivity into the near-infrared …
Proteomic map** of ER–PM junctions identifies STIMATE as a regulator of Ca2+ influx
Specialized junctional sites that connect the plasma membrane (PM) and endoplasmic
reticulum (ER) play critical roles in controlling lipid metabolism and Ca2+ signalling,,,. Store …
reticulum (ER) play critical roles in controlling lipid metabolism and Ca2+ signalling,,,. Store …