Genetic architecture: the shape of the genetic contribution to human traits and disease

NJ Timpson, CMT Greenwood, N Soranzo… - Nature Reviews …, 2018 - nature.com
Genetic architecture describes the characteristics of genetic variation that are responsible for
heritable phenotypic variability. It depends on the number of genetic variants affecting a trait …

The pleiotropic structure of the genotype–phenotype map: the evolvability of complex organisms

GP Wagner, J Zhang - Nature Reviews Genetics, 2011 - nature.com
It was first noticed 100 years ago that mutations tend to affect more than one phenotypic
characteristic, a phenomenon that was called'pleiotropy'. Because pleiotropy was found so …

Adaptation to an extraordinary environment by evolution of phenotypic plasticity and genetic assimilation

R Lande - Journal of evolutionary biology, 2009 - academic.oup.com
Adaptation to a sudden extreme change in environment, beyond the usual range of
background environmental fluctuations, is analysed using a quantitative genetic model of …

[BOOK][B] Phenotypic plasticity & evolution: causes, consequences, controversies

DW Pfennig - 2021 - library.oapen.org
Phenotypic plasticity–the ability of an individual organism to alter its features in direct
response to a change in its environment–is ubiquitous. Understanding how and why this …

Opportunities to improve resilience in animal breeding programs

TVL Berghof, M Poppe, HA Mulder - Frontiers in genetics, 2019 - frontiersin.org
Resilience is the capacity of an animal to be minimally affected by disturbances or to rapidly
return to the state pertained before exposure to a disturbance. However, indicators for …

Phenotypic plasticity: from theory and genetics to current and future challenges

RJ Sommer - Genetics, 2020 - academic.oup.com
Phenotypic plasticity is defined as the property of organisms to produce distinct phenotypes
in response to environmental variation. While for more than a century, biologists have …

The evolution of growth trajectories: what limits growth rate?

CM Dmitriew - Biological Reviews, 2011 - Wiley Online Library
According to life‐history theory, growth rates are subject to strong directional selection due
to reproductive and survival advantages associated with large adult body size. Yet, growth is …

Adaptation to marginal habitats

TJ Kawecki - Annual review of ecology, evolution, and …, 2008 - annualreviews.org
The ability to adapt to marginal habitats, in which survival and reproduction are initially poor,
plays a crucial role in the evolution of ecological niches and species ranges. Adaptation to …

Plasticity and robustness in development and evolution

P Bateson, P Gluckman - International Journal of Epidemiology, 2012 - academic.oup.com
Biology presents many wonders, but one of the most remarkable is how a complex
multicellular organism grows from a single cell. Until recently, the processes involved …

[BOOK][B] Mechanisms of life history evolution: the genetics and physiology of life history traits and trade-offs

T Flatt, A Heyland - 2011 - books.google.com
Life history theory seeks to explain the evolution of the major features of life cycles by
analyzing the ecological factors that shape age-specific schedules of growth, reproduction …