In the evolutionary battle between viruses and their hosts, viruses have armed themselves
with weapons to defeat the host's attacks on infected cells. Various proteins encoded in the …

Targeted therapy of cancer using oncolytic viruses has generated much interest over the
past few years in the light of the limited efficacy and side effects of standard cancer …

The human cytomegalovirus (HCMV) early glycoprotein products of the US11 and US2 open
reading frames cause increased turnover of major histocompatibility complex (MHC) class I …

Viral strategies for immune evasion include inhibition of various steps in the class I MHC
assembly pathway. Here, we demonstrate that adenovirus produces one gene product with …

Oncolytic replication-selective adenoviruses constitute a rapidly growing therapeutic
platform for cancer. However, the role of the host immune response and the E3 …

David H. Kirn, Editor tumor cell can cause cell destruction by several mechanisms (Table 1).
First, viral proteins, including the E3 11.6 adenovirus death protein (16) and E4ORF4 (17) …

The clinical utility of any cancer treatment is defined by both its antitumoral potency and its
therapeutic index between cancerous and normal cells. Chemotherapy for metastatic solid …

For decades cell biologists have relied on viruses to facilitate the study of complex cellular
function. More recently, the tragedy of the AIDS epidemic has focused considerable human …

Replication-competent viruses are used as selective cancer therapeutics and the
mechanisms leading to tumor-specific replication and antitumoral efficacy are now …

Human adenoviruses have been adopted as attractive vectors for in vivo gene therapy since
they have a well-characterized genomic organization, can be grown to high titres and …