RNA sample optimization for cryo-EM analysis
RNAs play critical roles in most biological processes. Although the three-dimensional (3D)
structures of RNAs primarily determine their functions, it remains challenging to …
structures of RNAs primarily determine their functions, it remains challenging to …
[HTML][HTML] Challenges, advances, and opportunities in RNA structural biology by Cryo-EM
SL Bonilla, K Jang - Current Opinion in Structural Biology, 2024 - Elsevier
RNAs are remarkably versatile molecules that can fold into intricate three-dimensional (3D)
structures to perform diverse cellular and viral functions. Despite their biological importance …
structures to perform diverse cellular and viral functions. Despite their biological importance …
Conformational penalties: New insights into nucleic acid recognition
Highlights•Conformational penalties to form alternative conformational states of nucleic
acids greatly contribute to nucleic acid-protein recognition.•Methods to determine nucleic …
acids greatly contribute to nucleic acid-protein recognition.•Methods to determine nucleic …
[HTML][HTML] Structural and biophysical dissection of RNA conformational ensembles
RNA's ability to form and interconvert between multiple secondary and tertiary structures is
critical to its functional versatility and the traditional view of RNA structures as static entities …
critical to its functional versatility and the traditional view of RNA structures as static entities …
Dissecting the Conformational Heterogeneity of Stem-Loop Substructures of the Fifth Element in the 5′-Untranslated Region of SARS-CoV-2
KR Mertinkus, A Oxenfarth, C Richter… - Journal of the …, 2024 - ACS Publications
Throughout the family of coronaviruses, structured RNA elements within the 5′ region of
the genome are highly conserved. The fifth stem-loop element from SARS-CoV-2 (5_SL5) …
the genome are highly conserved. The fifth stem-loop element from SARS-CoV-2 (5_SL5) …