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Excitotoxicity, calcium and mitochondria: a triad in synaptic neurodegeneration
Glutamate is the most commonly engaged neurotransmitter in the mammalian central
nervous system, acting to mediate excitatory neurotransmission. However, high levels of …
nervous system, acting to mediate excitatory neurotransmission. However, high levels of …
Mitochondrial calcium exchange in physiology and disease
The uptake of calcium into and extrusion of calcium from the mitochondrial matrix is a
fundamental biological process that has critical effects on cellular metabolism, signaling …
fundamental biological process that has critical effects on cellular metabolism, signaling …
[HTML][HTML] Generation of reactive oxygen species by mitochondria
Reactive oxygen species (ROS) are series of chemical products originated from one or
several electron reductions of oxygen. ROS are involved in physiology and disease and can …
several electron reductions of oxygen. ROS are involved in physiology and disease and can …
The machineries, regulation and cellular functions of mitochondrial calcium
Abstract Calcium ions (Ca2+) are some of the most versatile signalling molecules, and they
have many physiological functions, prominently including muscle contraction, neuronal …
have many physiological functions, prominently including muscle contraction, neuronal …
Role of mitochondrial calcium and the permeability transition pore in regulating cell death
Adult cardiomyocytes are postmitotic cells that undergo very limited cell division. Thus,
cardiomyocyte death as occurs during myocardial infarction has very detrimental …
cardiomyocyte death as occurs during myocardial infarction has very detrimental …
Determinants, maintenance, and function of organellar pH
The protonation state of soluble and membrane-associated macromolecules dictates their
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …
The mitochondrial permeability transition pore: an evolving concept critical for cell life and death
In this review, we summarize current knowledge of perhaps one of the most intriguing
phenomena in cell biology: the mitochondrial permeability transition pore (mPTP). This …
phenomena in cell biology: the mitochondrial permeability transition pore (mPTP). This …
Calcium dynamics as a machine for decoding signals
Calcium (Ca 2+) is considered one of the most-important biological cations, because it is
implicated in cell physiopathology and cell fate through a finely tuned signaling system. In …
implicated in cell physiopathology and cell fate through a finely tuned signaling system. In …
MICU3 is a tissue-specific enhancer of mitochondrial calcium uptake
The versatility and universality of Ca2+ as intracellular messenger is guaranteed by the
compartmentalization of changes in [Ca2+]. In this context, mitochondrial Ca2+ plays a …
compartmentalization of changes in [Ca2+]. In this context, mitochondrial Ca2+ plays a …
Mitochondrial Ca2+ signaling
Mitochondrial Ca 2+ regulation is crucial for bioenergetics and cellular signaling. The
mechanisms controlling mitochondrial calcium homeostasis have been recently unraveled …
mechanisms controlling mitochondrial calcium homeostasis have been recently unraveled …