β− Arrestins: structure, function, physiology, and pharmacological perspectives
The two β-arrestins, β-arrestin-1 and-2 (systematic names: arrestin-2 and-3, respectively),
are multifunctional intracellular proteins that regulate the activity of a very large number of …
are multifunctional intracellular proteins that regulate the activity of a very large number of …
Therapeutic potential of targeting ß-arrestin
ß-arrestins are multifunctional proteins that modulate heptahelical 7 transmembrane
receptors, also known as G protein-coupled receptors (GPCRs), a superfamily of receptors …
receptors, also known as G protein-coupled receptors (GPCRs), a superfamily of receptors …
β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility
Background β 2-adrenergic receptors (β 2 ARs) are the target of catecholamines and play
fundamental roles in cardiovascular, pulmonary, and skeletal muscle physiology. An …
fundamental roles in cardiovascular, pulmonary, and skeletal muscle physiology. An …
The role of β-arrestins in regulating stem cell phenotypes in normal and tumorigenic cells
G Kallifatidis, K Mamouni, BL Lokeshwar - International journal of …, 2020 - mdpi.com
β-Arrestins (ARRBs) are ubiquitously expressed scaffold proteins that mediate inactivation of
G-protein-coupled receptor signaling, and in certain circumstances, G-protein independent …
G-protein-coupled receptor signaling, and in certain circumstances, G-protein independent …
SUMOylation involves in β-arrestin-2-dependent metabolic regulation in breast cancer cell
C Dong, Y Li, Q Niu, H Fang, J Bai, Y Yan, C Gu… - Biochemical and …, 2020 - Elsevier
Abstract β-arrestin-2, a multifunctional adaptor protein, was originally identified as a
negative regulator of G protein–mediated signaling. We previously revealed that …
negative regulator of G protein–mediated signaling. We previously revealed that …
Di-arginine and FFAT-like motifs retain a subpopulation of PRA1 at ER-mitochondria membrane contact sites
A Abu Irqeba, JM Ogilvie - Plos one, 2020 - journals.plos.org
Prenylated Rab Acceptor 1 (PRA1/Rabac1) is a four-pass transmembrane protein that has
been found to localize to the Golgi and promiscuously associate with a diverse array of Rab …
been found to localize to the Golgi and promiscuously associate with a diverse array of Rab …