Rapid progress in molecular cancer biology coupled with the discovery of novel oncology
drugs has opened new horizons for cancer target discovery. As one of the crucial signaling …

Significance: Hypoxia is emerging as a crucial regulator of the tumor microenvironment; it
governs the metastatic potential of multiple primary cancers. It is also potentially involved in …

Sulforaphane belongs to the active class of isothiocyanates capable of delivering various
biological benefits for health promotion and disease prevention. This compound is …

Cisplatin is the most commonly used first-line drug for cancer treatment. However, many
patients develop resistance to cisplatin therapy which ultimately results in therapy failure …

Chemotherapy and radiotherapy are mainstay treatments for cancer patients. However, their
clinical outcomes are highly limited by the resistance of malignant tumors to these therapies …

Many energy metabolism pathways exist in cancer, including glycolysis, amino acid
metabolism, fatty acid oxidation, and mitochondrial respiration. Tumor cells mainly generate …

The role of immune system in carcinogenesis represents fundamental events associated
with cancer eradication; however, tumor evolution is connected with various mechanisms of …

Cancer is the world's second-largest cause of death. Although there are numerous cancer
treatment options, they are typically uncomfortable owing to side effects and ineffectual due …

The current pandemic forced us to introspect and revisit our armamentarium of medicinal
agents which could be life‐saving in emergency situations. Oxygen diffusion‐enhancing …

Hypoxia, a prevalent characteristic of both solid and liquid malignancies, is found to regulate
how genes are expressed in a way that promotes cellular adaptability and survival …