The major facilitator superfamily (MFS) is the largest known superfamily of secondary active
transporters. MFS transporters are responsible for transporting a broad spectrum of …

Background Tumors are highly plastic metabolic entities composed of cancer and host cells
that can adopt different metabolic phenotypes. For energy production, cancer cells may use …

Glioblastoma (GBM) is one of the most aggressive cancers of the brain. Despite extensive
research over the last several decades, the survival rates for GBM have not improved and …

Altered cellular metabolism is a hallmark of gliomas. Propelled by a set of recent
technological advances, new insights into the molecular mechanisms underlying glioma …

Herein, we use lessons learned in exercise physiology and metabolism to propose that
augmented lactate production ('lactagenesis'), initiated by gene mutations, is the reason and …

The emergence of OpenAI's ChatGPT has put intense spotlight on Generative AI (Gen-AI)
systems and their possible impacts on Academic integrity. This paper provides an overview …

Solute carrier (SLC) transporters—a family of more than 300 membrane-bound proteins that
facilitate the transport of a wide array of substrates across biological membranes—have …

While cancer is commonly described as “a disease of the genes,” it is also associated with
massive metabolic reprogramming that is now accepted as a disease “Hallmark.” This …

As a result of metabolic reprogramming, cancer cells display high rates of glycolysis,
causing an excess production of lactate along with an increase in extracellular acidity …

Malignant transformation of cells leads to enhanced glucose uptake and the conversion of a
larger fraction of pyruvate into lactate, even under normoxic conditions; this phenomenon of …