A key question in understanding microtubule dynamics is how GTP hydrolysis leads to
catastrophe, the switch from slow growth to rapid shrinkage. We first provide a review of the …

During eukaryote cell division, molecular motors are crucial regulators of microtubule
organization, spindle assembly, chromosome segregation and intracellular transport. The …

A high-resolution model of the microtubule has been obtained by docking the crystal
structure of tubulin into a 20 Å map of the microtubule. The excellent fit indicates the …

The aim of the book is to introduce the reader to the kinetic analysis of a wide range of
biological processes at the molecular level. It is intended to show that the same approach …

We developed a stochastic model of microtubule (MT) assembly dynamics that estimates
tubulin–tubulin bond energies, mechanical energy stored in the lattice dimers, and the size …

Microtubule self-assembly is largely governed by the chemical kinetics and thermodynamics
of tubulin-tubulin interactions. An important aspect of microtubule assembly is that hydrolysis …

Tubulin polymers, microtubules, can switch abruptly from the assembly to shortening. These
infrequent transitions, termed" catastrophes", affect numerous cellular processes but the …

Evidence that 13 or 14 contiguous tubulin-GTP subunits are sufficient to cap and stabilize a
microtubule end and that loss of only one of these subunits results in the transition to rapid …

Microtubules are cytoskeletal filaments whose self-assembly occurs by abrupt switching
between states of roughly constant growth and shrinkage, a process known as dynamic …

Recent studies have found that microtubule-associated proteins (MAPs) can regulate the
dynamical properties of microtubules in unexpected ways. For most MAPs, there is an …