Deazaguanine modifications play multifaceted roles in the molecular biology of DNA and
tRNA, sha** diverse yet essential biological processes, including the nuanced fine-tuning …

Seven-deazapurine modifications were thought to be highly specific of tRNAs, but have now
been discovered in DNA of phages and of phylogenetically diverse bacteria, illustrating the …

About half of known enzymatic reactions involve metals. Enzymes belonging to the same
superfamily often evolve to catalyze different reactions on the same structural scaffold. The …

The eukaryotic tRNA guanine transglycosylase (TGT) is an RNA modifying enzyme
incorporating queuine, a hypermodified guanine derivative, into the tRNAsAsp, Asn, His, Tyr …

Fermentative production of valuable substances is an economically competitive and
ecologically sustainable alternative to chemical synthesis, but it is often hampered by …

Eukaryotic tRNA guanine transglycosylase (TGT) is an RNA-modifying enzyme which
catalyzes the base exchange of the genetically encoded guanine 34 of tRNAs Asp, Asn, His …

RNA modifications have been implicated in diverse and important roles in all kingdoms of
life with over 100 of them present on tRNAs. A prominent modification at the wobble base of …

HMG-CoA reductase catalyzes the four-electron reduction of HMG-CoA to mevalonate and
is an enzyme of considerable biomedical relevance because of the impact of its statin …

The NADPH-dependent QueF nitrile reductases catalyze the unprecedented four-electron
reduction of nitrile to amine. QueF nitrile reductases can be found in the tRNA biosynthetic …

Bacterial tRNA-guanine transglycosylase (Tgt) catalyses the exchange of the genetically
encoded guanine at the wobble position of tRNAsHis, Tyr, Asp, Asn by the premodified base …