Kinase-targeted cancer therapies: progress, challenges and future directions
The human genome encodes 538 protein kinases that transfer a γ-phosphate group from
ATP to serine, threonine, or tyrosine residues. Many of these kinases are associated with …
ATP to serine, threonine, or tyrosine residues. Many of these kinases are associated with …
Protein kinase C: perfectly balanced
Protein kinase C (PKC) isozymes belong to a family of Ser/Thr kinases whose activity is
governed by reversible release of an autoinhibitory pseudosubstrate. For conventional and …
governed by reversible release of an autoinhibitory pseudosubstrate. For conventional and …
Protein kinase C, an elusive therapeutic target?
Protein kinase C (PKC) has been a tantalizing target for drug discovery ever since it was first
identified as the receptor for the tumour promoter phorbol ester in 1982. Although initial …
identified as the receptor for the tumour promoter phorbol ester in 1982. Although initial …
Optical trap** and manipulation of single cells using infrared laser beams
A Ashkin, JM Dziedzic, T Yamane - Nature, 1987 - nature.com
Use of optical traps for the manipulation of biological particles was recently proposed, and
initial observations of laser trap** of bacteria and viruses with visible argon-laser light …
initial observations of laser trap** of bacteria and viruses with visible argon-laser light …
Protein kinase C (PKC) isoforms in cancer, tumor promotion and tumor suppression
The AGC family of serine/threonine kinases (PKA, PKG, PKC) includes more than 60
members that are critical regulators of numerous cellular functions, including cell cycle and …
members that are critical regulators of numerous cellular functions, including cell cycle and …
The protein kinase family: conserved features and deduced phylogeny of the catalytic domains
In recent years, members of the protein kinase family have been discovered at an
accelerated pace. Most were first described, not through the traditional biochemical …
accelerated pace. Most were first described, not through the traditional biochemical …
Calcium control of neurotransmitter release
TC Südhof - Cold Spring Harbor perspectives in biology, 2012 - cshperspectives.cshlp.org
Upon entering a presynaptic terminal, an action potential opens Ca2+ channels, and
transiently increases the local Ca2+ concentration at the presynaptic active zone. Ca2+ then …
transiently increases the local Ca2+ concentration at the presynaptic active zone. Ca2+ then …
Protein kinase C: structure, function, and regulation
The protein kinase C family of enzymes transduces the myriad of signals promoting lipid
hydrolysis. The prevalence of this enzyme family in signaling is exemplified by the diverse …
hydrolysis. The prevalence of this enzyme family in signaling is exemplified by the diverse …
The extended protein kinase C superfamily
Members of the mammalian protein kinase C (PKC) superfamily play key regulatory roles in
a multitude of cellular processes, ranging from control of fundamental cell autonomous …
a multitude of cellular processes, ranging from control of fundamental cell autonomous …
The molecular heterogeneity of protein kinase C and its implications for cellular regulation
Y Nishizuka - Nature, 1988 - nature.com
Protein kinase C is now known to be a large family of proteins, with multiple subspecies that
have subtle individual enzymological characteristics. Some members of the family exhibit …
have subtle individual enzymological characteristics. Some members of the family exhibit …