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Photodynamic therapy—current limitations and novel approaches
Photodynamic therapy (PDT) mostly relies on the generation of singlet oxygen, via the
excitation of a photosensitizer, so that target tumor cells can be destroyed. PDT can be …
excitation of a photosensitizer, so that target tumor cells can be destroyed. PDT can be …
[HTML][HTML] Drug resistance and combating drug resistance in cancer
Cancer is the second leading cause of death in the US. Current major treatments for cancer
management include surgery, cytotoxic chemotherapy, targeted therapy, radiation therapy …
management include surgery, cytotoxic chemotherapy, targeted therapy, radiation therapy …
Excited-state intramolecular proton-transfer (ESIPT) based fluorescence sensors and imaging agents
In this review we will explore recent advances in the design and application of excited-state
intramolecular proton-transfer (ESIPT) based fluorescent probes. Fluorescence based …
intramolecular proton-transfer (ESIPT) based fluorescent probes. Fluorescence based …
Tumour acidosis: from the passenger to the driver's seat
The high metabolic demand of cancer cells leads to an accumulation of H+ ions in the
tumour microenvironment. The disorganized tumour vasculature prevents an efficient wash …
tumour microenvironment. The disorganized tumour vasculature prevents an efficient wash …
How the Warburg effect supports aggressiveness and drug resistance of cancer cells?
P Icard, S Shulman, D Farhat, JM Steyaert… - Drug Resistance …, 2018 - Elsevier
Cancer cells employ both conventional oxidative metabolism and glycolytic anaerobic
metabolism. However, their proliferation is marked by a shift towards increasing glycolytic …
metabolism. However, their proliferation is marked by a shift towards increasing glycolytic …
Nanocarrier cancer therapeutics with functional stimuli-responsive mechanisms
Presently, nanocarriers (NCs) have gained huge attention for their structural ability, good
biocompatibility, and biodegradability. The development of effective NCs with stimuli …
biocompatibility, and biodegradability. The development of effective NCs with stimuli …
Ion channels in cancer: are cancer hallmarks oncochannelopathies?
Genomic instability is a primary cause and fundamental feature of human cancer. However,
all cancer cell genotypes generally translate into several common pathophysiological …
all cancer cell genotypes generally translate into several common pathophysiological …
[HTML][HTML] ChatGPT and the rise of generative AI: Threat to academic integrity?
DO Eke - Journal of Responsible Technology, 2023 - Elsevier
The emergence of OpenAI's ChatGPT has put intense spotlight on Generative AI (Gen-AI)
systems and their possible impacts on Academic integrity. This paper provides an overview …
systems and their possible impacts on Academic integrity. This paper provides an overview …
TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells
Acidosis, a common characteristic of the tumor microenvironment, is associated with
alterations in metabolic preferences of cancer cells and progression of the disease. Here we …
alterations in metabolic preferences of cancer cells and progression of the disease. Here we …
[HTML][HTML] Classifying the evolutionary and ecological features of neoplasms
Neoplasms change over time through a process of cell-level evolution, driven by genetic
and epigenetic alterations. However, the ecology of the microenvironment of a neoplastic …
and epigenetic alterations. However, the ecology of the microenvironment of a neoplastic …