Photodynamic therapy—current limitations and novel approaches

G Gunaydin, ME Gedik, S Ayan - Frontiers in Chemistry, 2021 - frontiersin.org
Photodynamic therapy (PDT) mostly relies on the generation of singlet oxygen, via the
excitation of a photosensitizer, so that target tumor cells can be destroyed. PDT can be …

[HTML][HTML] Drug resistance and combating drug resistance in cancer

X Wang, H Zhang, X Chen - Cancer drug resistance, 2019 - ncbi.nlm.nih.gov
Cancer is the second leading cause of death in the US. Current major treatments for cancer
management include surgery, cytotoxic chemotherapy, targeted therapy, radiation therapy …

Excited-state intramolecular proton-transfer (ESIPT) based fluorescence sensors and imaging agents

AC Sedgwick, L Wu, HH Han, SD Bull, XP He… - Chemical Society …, 2018 - pubs.rsc.org
In this review we will explore recent advances in the design and application of excited-state
intramolecular proton-transfer (ESIPT) based fluorescent probes. Fluorescence based …

Tumour acidosis: from the passenger to the driver's seat

C Corbet, O Feron - Nature Reviews Cancer, 2017 - nature.com
The high metabolic demand of cancer cells leads to an accumulation of H+ ions in the
tumour microenvironment. The disorganized tumour vasculature prevents an efficient wash …

How the Warburg effect supports aggressiveness and drug resistance of cancer cells?

P Icard, S Shulman, D Farhat, JM Steyaert… - Drug Resistance …, 2018 - Elsevier
Cancer cells employ both conventional oxidative metabolism and glycolytic anaerobic
metabolism. However, their proliferation is marked by a shift towards increasing glycolytic …

Nanocarrier cancer therapeutics with functional stimuli-responsive mechanisms

N Kaushik, SB Borkar, SK Nandanwar… - Journal of …, 2022 - Springer
Presently, nanocarriers (NCs) have gained huge attention for their structural ability, good
biocompatibility, and biodegradability. The development of effective NCs with stimuli …

Ion channels in cancer: are cancer hallmarks oncochannelopathies?

N Prevarskaya, R Skryma, Y Shuba - Physiological reviews, 2018 - journals.physiology.org
Genomic instability is a primary cause and fundamental feature of human cancer. However,
all cancer cell genotypes generally translate into several common pathophysiological …

[HTML][HTML] ChatGPT and the rise of generative AI: Threat to academic integrity?

DO Eke - Journal of Responsible Technology, 2023 - Elsevier
The emergence of OpenAI's ChatGPT has put intense spotlight on Generative AI (Gen-AI)
systems and their possible impacts on Academic integrity. This paper provides an overview …

TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells

C Corbet, E Bastien, JP Santiago de Jesus… - Nature …, 2020 - nature.com
Acidosis, a common characteristic of the tumor microenvironment, is associated with
alterations in metabolic preferences of cancer cells and progression of the disease. Here we …

[HTML][HTML] Classifying the evolutionary and ecological features of neoplasms

CC Maley, A Aktipis, TA Graham, A Sottoriva… - Nature Reviews …, 2017 - nature.com
Neoplasms change over time through a process of cell-level evolution, driven by genetic
and epigenetic alterations. However, the ecology of the microenvironment of a neoplastic …