Thirty years of density functional theory in computational chemistry: an overview and extensive assessment of 200 density functionals

N Mardirossian, M Head-Gordon - Molecular physics, 2017 - Taylor & Francis
In the past 30 years, Kohn–Sham density functional theory has emerged as the most popular
electronic structure method in computational chemistry. To assess the ever-increasing …

Computational Prediction of 1H and 13C Chemical Shifts: A Useful Tool for Natural Product, Mechanistic, and Synthetic Organic Chemistry

MW Lodewyk, MR Siebert, DJ Tantillo - Chemical Reviews, 2012 - ACS Publications
Quantum mechanical calculations of magnetic behavior in molecules are present in the
literature dating at least as far back as London's treatment of diamagnetic anisotropy in …

A guide to small-molecule structure assignment through computation of (1H and 13C) NMR chemical shifts

PH Willoughby, MJ Jansma, TR Hoye - Nature protocols, 2014 - nature.com
This protocol is intended to provide chemists who discover or make new organic compounds
with a valuable tool for validating the structural assignments of those new chemical entities …

Computational chemistry to the rescue: Modern toolboxes for the assignment of complex molecules by GIAO NMR calculations

N Grimblat, AM Sarotti - Chemistry–A European Journal, 2016 - Wiley Online Library
The calculations of NMR properties of molecules using quantum chemical methods have
deeply impacted several branches of organic chemistry. They are particularly important in …

Dissipative assembly of aqueous carboxylic acid anhydrides fueled by carbodiimides

LS Kariyawasam, CS Hartley - Journal of the American Chemical …, 2017 - ACS Publications
Biochemical systems make extensive use of chemically fueled processes (eg, using ATP),
but analogous abiotic systems remain rare. A key challenge is the identification of …

Structural characterisation of natural products by means of quantum chemical calculations of NMR parameters: New insights

FLP Costa, ACF de Albuquerque, RG Fiorot… - Organic Chemistry …, 2021 - pubs.rsc.org
In the early 2000s, the first articles regarding the calculation of NMR parameters for natural
products appeared in the literature. Since then, modelling 1H and 13C chemical shifts and …

Quantum-Chemical Simulation of 1H NMR Spectra. 2. Comparison of DFT-Based Procedures for Computing Proton–Proton Coupling Constants in Organic Molecules

T Bally, PR Rablen - The Journal of organic chemistry, 2011 - ACS Publications
The performance of 250 different computational protocols (combinations of density
functionals, basis sets and methods) was assessed on a set of 165 well-established …

A Multi-standard Approach for GIAO 13C NMR Calculations

AM Sarotti, SC Pellegrinet - The Journal of organic chemistry, 2009 - ACS Publications
The influence of the reference standard employed in the calculation of 13C NMR chemical
shifts was investigated over a large variety of known organic compounds, using different …

Electrochemically driven desaturation of carbonyl compounds

S Gnaim, Y Takahira, HR Wilke, Z Yao, J Li… - Nature …, 2021 - nature.com
Electrochemical techniques have long been heralded for their innate sustainability as
efficient methods to achieve redox reactions. Carbonyl desaturation, as a fundamental …

Total Synthesis of Oxidized Welwitindolinones and (−)-N-Methylwelwitindolinone C Isonitrile

KW Quasdorf, AD Huters, MW Lodewyk… - Journal of the …, 2012 - ACS Publications
We report the total synthesis of (−)-N-methylwelwitindolinone C isonitrile, in addition to the
total syntheses of the 3-hydroxylated welwitindolinones. Our routes to these elusive natural …