Free radicals are chemical particles containing one or more unpaired electrons, which may
be part of the molecule. They cause the molecule to become highly reactive. The free …

The brain is a singular organ of unique biological complexity that serves as the command
center for cognitive and motor function. As such, this specialized system also possesses a …

▪ Abstract Metallothioneins (MT) are low-molecular-weight, cysteine-rich, metal-binding
proteins. MT genes are readily induced by various physiologic and toxicologic stimuli …

We postulate a novel and general mechanism in which the redox-active sulfur donor group
of cyst (e) ine confers oxidoreductive characteristics on stable zinc sites in proteins. Thus …

To search for novel transcriptional pathways that are activated in skeletal muscle after
endurance exercise, we used cDNA microarrays to measure global mRNA expression after …

Copper, zinc and iron are essential metals for different physiological functions, even though
their excess can lead to biological damage. This review provides a background of toxicity …

Due to ultra-high reactivity, direct determination of free radicals, especially hydroxyl radical (•
OH) with ultra-short lifetime, by field-effect transistor (FET) sensors remains a challenge …

Zinc/cysteine coordination environments in proteins are redox-active. Oxidation of the sulfur
ligands mobilizes zinc, while reduction of the oxidized ligands enhances zinc binding …

The antioxidant function of metallothionein (MT) was first suggested in the early 1980s.
Studies in vitro have revealed that MT reacts directly with reactive oxygen species, including …

In the world of chemistry and mineralogy, the mutual affinity of zinc and sulfur is well-
recognized. The earliest detected modes of zinc coordination in biology were different …