Updates on lung adenocarcinoma: invasive size, grading and STAS

J Willner, N Narula, AL Moreira - Histopathology, 2024 - Wiley Online Library
Advancements in the classification of lung adenocarcinoma have resulted in significant
changes in pathological reporting. The eighth edition of the tumour–node–metastasis (TNM) …

Micropapillary structure: A natural tumor collective invasion model with enhanced stem‐like properties

S Li, S Gao, L Qin, C Ding, J Qu, Y Cui, L Qiang… - Cancer …, 2025 - Wiley Online Library
Cancer stem cells aggregate to form clusters, which have enhanced stem‐like properties
and metastasis potential. However, the molecular mechanisms underlying the formation of …

A new model using deep learning to predict recurrence after surgical resection of lung adenocarcinoma

PJ Kim, HS Hwang, G Choi, HJ Sung, B Ahn, JS Uh… - Scientific Reports, 2024 - nature.com
This study aimed to develop a deep learning (DL) model for predicting the recurrence risk of
lung adenocarcinoma (LUAD) based on its histopathological features. Clinicopathological …

Micropapillary and solid components as high-grade patterns in IASLC grading system of lung adenocarcinoma: Clinical implications and management

M Mikubo, S Tamagawa, Y Kondo, S Hayashi… - Lung Cancer, 2024 - Elsevier
Objectives The grading system proposed by the International Association for the Study of
Lung Cancer is based on a combination of predominant histologic subtypes and the …

[HTML][HTML] Who benefit from adjuvant chemotherapy in stage I lung adenocarcinoma? A multi-dimensional model for candidate selection

M Jiang, L Qian, Y Shen, Y Fu, W Feng, Z Ding, Y Han… - Neoplasia, 2024 - Elsevier
Background Despite promising overall survival of stage I lung adenocarcinoma (LUAD)
patients, 10-25% of them still went through recurrence after surgery.[1] While it is still …

[HTML][HTML] Efficacy of preoperative biopsy in predicting the newly proposed histologic grade of resected lung adenocarcinoma

SJ Ohtani-Kim, T Taki, K Tane, T Miyoshi, J Samejima… - Modern Pathology, 2023 - Elsevier
A novel histologic grading system for invasive lung adenocarcinomas (LUAD) has been
newly proposed and adopted by the World Health Organization (WHO) classification. We …

Enhanced CT-Based Intratumoral and Peritumoral Radiomics Nomograms Predict High-Grade Patterns of Invasive Lung Adenocarcinoma

J Xu, L Liu, Y Ji, T Yan, Z Shi, H Pan, S Wang, K Yu… - Academic …, 2025 - Elsevier
Rationale and Objectives Extraction of intratumoral and peritumoral radiomics features
combined with clinical factors to establish nomograms to predict high-grade patterns …

An oncogenic CTNNB1 mutation is predictive of post-operative recurrence-free survival in an EGFR-mutant lung adenocarcinoma

Y Kim, B Ahn, S Yoon, G Lee, D Kim, SM Chun… - Plos one, 2023 - journals.plos.org
The Wnt/β-catenin pathway is known to be frequently dysregulated in various human
malignancies. Alterations in the genes encoding the components of Wnt/β-catenin pathway …

Clinicopathologic and genomic analyses of SMARCA4-mutated non-small cell lung carcinoma implicate the needs for tailored treatment strategies

B Ahn, D Kim, W Ji, SM Chun, G Lee, SJ Jang… - Lung Cancer, 2025 - Elsevier
Background The clinicopathologic and therapeutic significance of SMARCA4 mutation in
non-small cell lung carcinoma (NSCLC) remains unclear. Methods We retrieved 575 …

[HTML][HTML] Clinical Impact of Genomic and Pathway Alterations in Stage I EGFR-Mutant Lung Adenocarcinoma

JS Lee, EK Kim, KA Kim, HS Shim - Cancer Research and …, 2024 - ncbi.nlm.nih.gov
Purpose We investigated the clinical impact of genomic and pathway alterations in stage I
epidermal growth factor receptor (EGFR)–mutant lung adenocarcinomas, which have a high …