Mycobacterium tuberculosis is primarily a respiratory pathogen. However, 15% of infections
worldwide occur at extrapulmonary sites causing additional complications for diagnosis and …

Tuberculosis (TB) remains a major public health problem internationally, causing 9.6 million
new cases and 1.5 million deaths worldwide in 2014. The Bacillus Calmette-Guérin vaccine …

Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is one of the most important
infectious diseases globally. Immune effector mechanisms that lead to protection or …

Tuberculosis (TB) is still responsible for the deaths of> 1 million people yearly worldwide,
and therefore its correct diagnosis is one of the key components of any TB eradication …

Rationale: Tuberculosis (TB) remains a leading cause of death, and the role of T-cell
responses to control Mycobacterium tuberculosis infections is well recognized. Patients with …

In this study, we evaluated the potential of a novel synthetic adjuvant designated IC31 for the
ability to augment the immune response and protective efficacy of the well-known …

Mycobacterial heparin-binding haemagglutinin antigen (HBHA) is a virulence factor that
induces apoptosis of macrophages. Endoplasmic reticulum (ER) stress-mediated apoptosis …

Tuberculosis (TB) remains a major global health problem despite widespread use of the
Bacillus BCG vaccine. This situation is worsened by co-infection with HIV, and the …

The heparin-binding hemagglutinin adhesin (HBHA) is an important virulence factor of
Mycobacterium tuberculosis. It is a surface-displayed protein that serves as an adhesin for …

As part of a major project to investigate protective and diagnostic immune markers against
tuberculosis (TB), we measured antibody isotype responses to Mycobacterium tuberculosis …